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A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein.
Zeller J, Cheung Tung Shing KS, Nero TL, McFadyen JD, Krippner G, Bogner B, Kreuzaler S, Kiefer J, Horner VK, Braig D, Danish H, Baratchi S, Fricke M, Wang X, Kather MG, Kammerer B, Woollard KJ, Sharma P, Morton CJ, Pietersz G, Parker MW, Peter K, Eisenhardt SU. Zeller J, et al. Among authors: sharma p. EMBO Mol Med. 2023 Jan 11;15(1):e16236. doi: 10.15252/emmm.202216236. Epub 2022 Dec 5. EMBO Mol Med. 2023. PMID: 36468184 Free PMC article.
Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation.
Zeller J, Loseff-Silver J, Khoshmanesh K, Baratchi S, Lai A, Nero TL, Roy A, Watson A, Dayawansa N, Sharma P, Barbaro-Wahl A, Chen YC, Moon M, Vidallon MLP, Huang A, Thome J, Cheung Tung Shing KS, Harvie D, Bongiovanni MN, Braig D, Morton CJ, Htun NM, Stub D, Walton A, Horowitz J, Wang X, Pietersz G, Parker MW, Eisenhardt SU, McFadyen JD, Peter K. Zeller J, et al. Among authors: sharma p. Circ Res. 2024 Nov 8;135(11):1033-1047. doi: 10.1161/CIRCRESAHA.124.324248. Epub 2024 Oct 18. Circ Res. 2024. PMID: 39421928 Free PMC article.
IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice.
Thomas JM, Ling YH, Huuskes B, Jelinic M, Sharma P, Saini N, Ferens DM, Diep H, Krishnan SM, Kemp-Harper BK, O'Connor PM, Latz E, Arumugam TV, Guzik TJ, Hickey MJ, Mansell A, Sobey CG, Vinh A, Drummond GR. Thomas JM, et al. Among authors: sharma p. Hypertension. 2021 Nov;78(5):1296-1309. doi: 10.1161/HYPERTENSIONAHA.120.16437. Epub 2021 Sep 7. Hypertension. 2021. PMID: 34488433 Free article.
Interplay between periodontitis and chronic kidney disease.
Chapple ILC, Hirschfeld J, Cockwell P, Dietrich T, Sharma P. Chapple ILC, et al. Among authors: sharma p. Nat Rev Nephrol. 2024 Dec 10. doi: 10.1038/s41581-024-00910-5. Online ahead of print. Nat Rev Nephrol. 2024. PMID: 39658571 Review.
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