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AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase.
Yoshihama Y, LaBella KA, Kim E, Bertolet L, Colic M, Li J, Shang X, Wu CJ, Spring DJ, Wang YA, Hart T, DePinho RA. Yoshihama Y, et al. Among authors: labella ka. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2026324118. doi: 10.1073/pnas.2026324118. Proc Natl Acad Sci U S A. 2021. PMID: 34475205 Free PMC article.
Telomere dysfunction activates YAP1 to drive tissue inflammation.
Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. Chakravarti D, et al. Among authors: labella ka. Nat Commun. 2020 Sep 21;11(1):4766. doi: 10.1038/s41467-020-18420-w. Nat Commun. 2020. PMID: 32958778 Free PMC article.
Telomeres: history, health, and hallmarks of aging.
Chakravarti D, LaBella KA, DePinho RA. Chakravarti D, et al. Among authors: labella ka. Cell. 2021 Jan 21;184(2):306-322. doi: 10.1016/j.cell.2020.12.028. Epub 2021 Jan 14. Cell. 2021. PMID: 33450206 Free PMC article. Review.
Histone demethylase KDM5D upregulation drives sex differences in colon cancer.
Li J, Lan Z, Liao W, Horner JW, Xu X, Liu J, Yoshihama Y, Jiang S, Shim HS, Slotnik M, LaBella KA, Wu CJ, Dunner K Jr, Hsu WH, Lee R, Khanduri I, Terranova C, Akdemir K, Chakravarti D, Shang X, Spring DJ, Wang YA, DePinho RA. Li J, et al. Among authors: labella ka. Nature. 2023 Jul;619(7970):632-639. doi: 10.1038/s41586-023-06254-7. Epub 2023 Jun 21. Nature. 2023. PMID: 37344599 Free PMC article.
Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression.
Hsu WH, LaBella KA, Lin Y, Xu P, Lee R, Hsieh CE, Yang L, Zhou A, Blecher JM, Wu CJ, Lin K, Shang X, Jiang S, Spring DJ, Xia Y, Chen P, Shen JP, Kopetz S, DePinho RA. Hsu WH, et al. Among authors: labella ka. Cancer Discov. 2023 Dec 12;13(12):2652-2673. doi: 10.1158/2159-8290.CD-22-1467. Cancer Discov. 2023. PMID: 37768068 Free PMC article.
Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer.
Han J, Xu J, Liu Y, Liang S, LaBella KA, Chakravarti D, Spring DJ, Xia Y, DePinho RA. Han J, et al. Among authors: labella ka. Genes Dev. 2023 Sep 1;37(17-18):818-828. doi: 10.1101/gad.351037.123. Epub 2023 Sep 29. Genes Dev. 2023. PMID: 37775182 Free PMC article.
Telomere dysfunction alters intestinal stem cell dynamics to promote cancer.
LaBella KA, Hsu WH, Li J, Qi Y, Liu Y, Liu J, Wu CC, Liu Y, Song Z, Lin Y, Blecher JM, Jiang S, Shang X, Han J, Spring DJ, Zhang J, Xia Y, DePinho RA. LaBella KA, et al. Dev Cell. 2024 Jun 3;59(11):1475-1486.e5. doi: 10.1016/j.devcel.2024.03.020. Epub 2024 Apr 3. Dev Cell. 2024. PMID: 38574731
Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.
Chaturantabut S, Shwartz A, Evason KJ, Cox AG, Labella K, Schepers AG, Yang S, Acuña M, Houvras Y, Mancio-Silva L, Romano S, Gorelick DA, Cohen DE, Zon LI, Bhatia SN, North TE, Goessling W. Chaturantabut S, et al. Gastroenterology. 2019 May;156(6):1788-1804.e13. doi: 10.1053/j.gastro.2019.01.010. Epub 2019 Jan 12. Gastroenterology. 2019. PMID: 30641053 Free PMC article.
14 results