De Smidt E - Search Results

1

Improved Potency and Safety of DNA-Encoded Antibody Therapeutics Through Plasmid Backbone and Expression Cassette Engineering.

Vermeire G, De Smidt E, Geukens N, Williams JA, Declerck P, Hollevoet K. Vermeire G, et al. Among authors: de smidt e. Hum Gene Ther. 2021 Oct;32(19-20):1200-1209. doi: 10.1089/hum.2021.105. Hum Gene Ther. 2021. PMID: 34482757

2

Bridging the Clinical Gap for DNA-Based Antibody Therapy Through Translational Studies in Sheep.

Hollevoet K, De Vleeschauwer S, De Smidt E, Vermeire G, Geukens N, Declerck P. Hollevoet K, et al. Among authors: de smidt e. Hum Gene Ther. 2019 Nov;30(11):1431-1443. doi: 10.1089/hum.2019.128. Epub 2019 Sep 10. Hum Gene Ther. 2019. PMID: 31382777

3

DNA-Based Delivery of Checkpoint Inhibitors in Muscle and Tumor Enables Long-Term Responses with Distinct Exposure.

Jacobs L, De Smidt E, Geukens N, Declerck P, Hollevoet K. Jacobs L, et al. Among authors: de smidt e. Mol Ther. 2020 Apr 8;28(4):1068-1077. doi: 10.1016/j.ymthe.2020.02.007. Epub 2020 Feb 13. Mol Ther. 2020. PMID: 32101701 Free PMC article.

4

DNA-based delivery of anti-DR5 Nanobodies improves exposure and anti-tumor efficacy over protein-based administration.

Vermeire G, De Smidt E, Casteels P, Geukens N, Declerck P, Hollevoet K. Vermeire G, et al. Among authors: de smidt e. Cancer Gene Ther. 2021 Aug;28(7-8):828-838. doi: 10.1038/s41417-020-0204-9. Epub 2020 Jul 30. Cancer Gene Ther. 2021. PMID: 32733055

5

Clinically relevant dosing and pharmacokinetics of DNA-encoded antibody therapeutics in a sheep model.

Hollevoet K, Thomas D, Compernolle G, Vermeire G, De Smidt E, De Vleeschauwer S, Smith TRF, Fisher PD, Dewilde M, Geukens N, Declerck P. Hollevoet K, et al. Among authors: de smidt e. Front Oncol. 2022 Oct 3;12:1017612. doi: 10.3389/fonc.2022.1017612. eCollection 2022. Front Oncol. 2022. PMID: 36263202 Free PMC article.

6

Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies.

Hollevoet K, De Smidt E, Geukens N, Declerck P. Hollevoet K, et al. Among authors: de smidt e. Oncotarget. 2018 Feb 6;9(17):13623-13636. doi: 10.18632/oncotarget.24426. eCollection 2018 Mar 2. Oncotarget. 2018. PMID: 29568382 Free PMC article.

7

Electroporation outperforms in vivo-jetPEI for intratumoral DNA-based reporter gene transfer.

Jacobs L, De Smidt E, Geukens N, Declerck P, Hollevoet K. Jacobs L, et al. Among authors: de smidt e. Sci Rep. 2020 Nov 11;10(1):19532. doi: 10.1038/s41598-020-75206-2. Sci Rep. 2020. PMID: 33177564 Free PMC article.

8

A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms.

Verelst J, Geukens N, Eddarkaoui S, Vliegen D, De Smidt E, Rosseels J, Franssens V, Molenberghs S, Francois C, Stoops E, Bjerke M, Engelborghs S, Laghmouchi M, Carmans S, Buée L, Vanmechelen E, Winderickx J, Thomas D. Verelst J, et al. Among authors: de smidt e. Front Mol Biosci. 2020 Mar 31;7:48. doi: 10.3389/fmolb.2020.00048. eCollection 2020. Front Mol Biosci. 2020. PMID: 32296712 Free PMC article.

9

MIF inhibition interferes with the inflammatory and T cell-stimulatory capacity of NOD macrophages and delays autoimmune diabetes onset.

Korf H, Breser L, Van Hoeck J, Godoy J, Cook DP, Stijlemans B, De Smidt E, Moyson C, Monteiro Carvalho Mori Cunha JP, Rivero V, Gysemans C, Mathieu C. Korf H, et al. Among authors: de smidt e. PLoS One. 2017 Nov 2;12(11):e0187455. doi: 10.1371/journal.pone.0187455. eCollection 2017. PLoS One. 2017. PMID: 29095944 Free PMC article.

10

Vitamin D deficiency exacerbates COPD-like characteristics in the lungs of cigarette smoke-exposed mice.

Heulens N, Korf H, Cielen N, De Smidt E, Maes K, Gysemans C, Verbeken E, Gayan-Ramirez G, Mathieu C, Janssens W. Heulens N, et al. Among authors: de smidt e. Respir Res. 2015 Sep 16;16(1):110. doi: 10.1186/s12931-015-0271-x. Respir Res. 2015. PMID: 26376849 Free PMC article.

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