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Page 1
Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease.
Pearsall RS, Davies MV, Cannell M, Li J, Widrick J, Mulivor AW, Wallner S, Troy ME, Spaits M, Liharska K, Sako D, Castonguay R, Keates S, Grinberg AV, Suragani RNVS, Kumar R. Pearsall RS, et al. Among authors: liharska k. Sci Rep. 2019 Aug 6;9(1):11392. doi: 10.1038/s41598-019-47818-w. Sci Rep. 2019. PMID: 31388039 Free PMC article.
ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders.
Li J, Fredericks M, Cannell M, Wang K, Sako D, Maguire MC, Grenha R, Liharska K, Krishnan L, Bloom T, Belcheva EP, Martinez PA, Castonguay R, Keates S, Alexander MJ, Choi H, Grinberg AV, Pearsall RS, Oh P, Kumar R, Suragani RN. Li J, et al. Among authors: liharska k. J Clin Invest. 2021 Feb 15;131(4):e138634. doi: 10.1172/JCI138634. J Clin Invest. 2021. PMID: 33586684 Free PMC article.
A novel therapeutic approach to treating obesity through modulation of TGFβ signaling.
Koncarevic A, Kajimura S, Cornwall-Brady M, Andreucci A, Pullen A, Sako D, Kumar R, Grinberg AV, Liharska K, Ucran JA, Howard E, Spiegelman BM, Seehra J, Lachey J. Koncarevic A, et al. Among authors: liharska k. Endocrinology. 2012 Jul;153(7):3133-46. doi: 10.1210/en.2012-1016. Epub 2012 May 1. Endocrinology. 2012. PMID: 22549226 Free PMC article.
Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle.
Castonguay R, Lachey J, Wallner S, Strand J, Liharska K, Watanabe AE, Cannell M, Davies MV, Sako D, Troy ME, Krishnan L, Mulivor AW, Li H, Keates S, Alexander MJ, Pearsall RS, Kumar R. Castonguay R, et al. Among authors: liharska k. J Pharmacol Exp Ther. 2019 Mar;368(3):435-445. doi: 10.1124/jpet.118.252304. Epub 2018 Dec 18. J Pharmacol Exp Ther. 2019. PMID: 30563942
A soluble activin receptor type IIb prevents the effects of androgen deprivation on body composition and bone health.
Koncarevic A, Cornwall-Brady M, Pullen A, Davies M, Sako D, Liu J, Kumar R, Tomkinson K, Baker T, Umiker B, Monnell T, Grinberg AV, Liharska K, Underwood KW, Ucran JA, Howard E, Barberio J, Spaits M, Pearsall S, Seehra J, Lachey J. Koncarevic A, et al. Among authors: liharska k. Endocrinology. 2010 Sep;151(9):4289-300. doi: 10.1210/en.2010-0134. Epub 2010 Jun 23. Endocrinology. 2010. PMID: 20573726
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength.
Baud'huin M, Solban N, Cornwall-Brady M, Sako D, Kawamoto Y, Liharska K, Lath D, Bouxsein ML, Underwood KW, Ucran J, Kumar R, Pobre E, Grinberg A, Seehra J, Canalis E, Pearsall RS, Croucher PI. Baud'huin M, et al. Among authors: liharska k. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12207-12. doi: 10.1073/pnas.1204929109. Epub 2012 Jul 3. Proc Natl Acad Sci U S A. 2012. PMID: 22761317 Free PMC article.