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Page 1
Rational design of a new antibiotic class for drug-resistant infections.
Durand-Reville TF, Miller AA, O'Donnell JP, Wu X, Sylvester MA, Guler S, Iyer R, Shapiro AB, Carter NM, Velez-Vega C, Moussa SH, McLeod SM, Chen A, Tanudra AM, Zhang J, Comita-Prevoir J, Romero JA, Huynh H, Ferguson AD, Horanyi PS, Mayclin SJ, Heine HS, Drusano GL, Cummings JE, Slayden RA, Tommasi RA. Durand-Reville TF, et al. Among authors: horanyi ps. Nature. 2021 Sep;597(7878):698-702. doi: 10.1038/s41586-021-03899-0. Epub 2021 Sep 15. Nature. 2021. PMID: 34526714
Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506.
Cole AG, Kultgen SG, Mani N, Quintero JG, Yi Fan K, Ardzinski A, Stever K, Dorsey BD, Phelps JR, Lee ACH, Thi EP, Chiu T, Tang S, Horanyi PS, Mayclin SJ, Harasym TO, Sofia MJ. Cole AG, et al. Among authors: horanyi ps. Bioorg Med Chem Lett. 2023 Oct 1;94:129456. doi: 10.1016/j.bmcl.2023.129456. Epub 2023 Aug 25. Bioorg Med Chem Lett. 2023. PMID: 37633618
Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants.
Mittal A, Martin MF, Levin EJ, Adams C, Yang M, Provins L, Hall A, Procter M, Ledecq M, Hillisch A, Wolff C, Gillard M, Horanyi PS, Coleman JA. Mittal A, et al. Among authors: horanyi ps. Nat Struct Mol Biol. 2024 Jun 19. doi: 10.1038/s41594-024-01335-1. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38898101
Structures of glyceraldehyde 3-phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis.
Barrett KF, Dranow DM, Phan IQ, Michaels SA, Shaheen S, Navaluna ED, Craig JK, Tillery LM, Choi R, Edwards TE, Conrady DG, Abendroth J, Horanyi PS, Lorimer DD, Van Voorhis WC, Zhang Z, Barrett LK, Subramanian S, Staker B, Fan E, Myler PJ, Soge OO, Hybiske K, Ojo KK. Barrett KF, et al. Among authors: horanyi ps. Protein Sci. 2020 Mar;29(3):768-778. doi: 10.1002/pro.3824. Epub 2020 Jan 28. Protein Sci. 2020. PMID: 31930578 Free PMC article.
Structure of the integral membrane protein CAAX protease Ste24p.
Pryor EE Jr, Horanyi PS, Clark KM, Fedoriw N, Connelly SM, Koszelak-Rosenblum M, Zhu G, Malkowski MG, Wiener MC, Dumont ME. Pryor EE Jr, et al. Among authors: horanyi ps. Science. 2013 Mar 29;339(6127):1600-4. doi: 10.1126/science.1232048. Science. 2013. PMID: 23539602 Free PMC article.
14 results