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Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy.
Bhatia TN, Clark RN, Needham PG, Miner KM, Jamenis AS, Eckhoff EA, Abraham N, Hu X, Wipf P, Luk KC, Brodsky JL, Leak RK. Bhatia TN, et al. Among authors: brodsky jl. Neurotherapeutics. 2021 Oct;18(4):2541-2564. doi: 10.1007/s13311-021-01114-6. Epub 2021 Sep 15. Neurotherapeutics. 2021. PMID: 34528172 Free PMC article.
Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.
Chiang AN, Valderramos JC, Balachandran R, Chovatiya RJ, Mead BP, Schneider C, Bell SL, Klein MG, Huryn DM, Chen XS, Day BW, Fidock DA, Wipf P, Brodsky JL. Chiang AN, et al. Among authors: brodsky jl. Bioorg Med Chem. 2009 Feb 15;17(4):1527-33. doi: 10.1016/j.bmc.2009.01.024. Epub 2009 Jan 20. Bioorg Med Chem. 2009. PMID: 19195901 Free PMC article.
Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock.
Botha M, Chiang AN, Needham PG, Stephens LL, Hoppe HC, Külzer S, Przyborski JM, Lingelbach K, Wipf P, Brodsky JL, Shonhai A, Blatch GL. Botha M, et al. Among authors: brodsky jl. Cell Stress Chaperones. 2011 Jul;16(4):389-401. doi: 10.1007/s12192-010-0250-6. Epub 2010 Dec 30. Cell Stress Chaperones. 2011. PMID: 21191678 Free PMC article.
Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.
Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P. Huryn DM, et al. Among authors: brodsky jl. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62. doi: 10.1073/pnas.1015251108. Epub 2011 Apr 18. Proc Natl Acad Sci U S A. 2011. PMID: 21502524 Free PMC article.
291 results