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Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy.
Bhatia TN, Clark RN, Needham PG, Miner KM, Jamenis AS, Eckhoff EA, Abraham N, Hu X, Wipf P, Luk KC, Brodsky JL, Leak RK. Bhatia TN, et al. Among authors: wipf p. Neurotherapeutics. 2021 Oct;18(4):2541-2564. doi: 10.1007/s13311-021-01114-6. Epub 2021 Sep 15. Neurotherapeutics. 2021. PMID: 34528172 Free PMC article.
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G. Rodina A, et al. Among authors: wipf p. Nat Chem Biol. 2007 Aug;3(8):498-507. doi: 10.1038/nchembio.2007.10. Epub 2007 Jul 1. Nat Chem Biol. 2007. PMID: 17603540
Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.
Chiang AN, Valderramos JC, Balachandran R, Chovatiya RJ, Mead BP, Schneider C, Bell SL, Klein MG, Huryn DM, Chen XS, Day BW, Fidock DA, Wipf P, Brodsky JL. Chiang AN, et al. Among authors: wipf p. Bioorg Med Chem. 2009 Feb 15;17(4):1527-33. doi: 10.1016/j.bmc.2009.01.024. Epub 2009 Jan 20. Bioorg Med Chem. 2009. PMID: 19195901 Free PMC article.
Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock.
Botha M, Chiang AN, Needham PG, Stephens LL, Hoppe HC, Külzer S, Przyborski JM, Lingelbach K, Wipf P, Brodsky JL, Shonhai A, Blatch GL. Botha M, et al. Among authors: wipf p. Cell Stress Chaperones. 2011 Jul;16(4):389-401. doi: 10.1007/s12192-010-0250-6. Epub 2010 Dec 30. Cell Stress Chaperones. 2011. PMID: 21191678 Free PMC article.
459 results