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Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.
Meyer B, Chiaravalli J, Gellenoncourt S, Brownridge P, Bryne DP, Daly LA, Grauslys A, Walter M, Agou F, Chakrabarti LA, Craik CS, Eyers CE, Eyers PA, Gambin Y, Jones AR, Sierecki E, Verdin E, Vignuzzi M, Emmott E. Meyer B, et al. Among authors: daly la. Nat Commun. 2021 Sep 21;12(1):5553. doi: 10.1038/s41467-021-25796-w. Nat Commun. 2021. PMID: 34548480 Free PMC article.
Mechanism of glycogen synthase inactivation and interaction with glycogenin.
Marr L, Biswas D, Daly LA, Browning C, Vial SCM, Maskell DP, Hudson C, Bertrand JA, Pollard J, Ranson NA, Khatter H, Eyers CE, Sakamoto K, Zeqiraj E. Marr L, et al. Among authors: daly la. Nat Commun. 2022 Jun 11;13(1):3372. doi: 10.1038/s41467-022-31109-6. Nat Commun. 2022. PMID: 35690592 Free PMC article.
Mislocalization of protein kinase A drives pathology in Cushing's syndrome.
Omar MH, Byrne DP, Jones KN, Lakey TM, Collins KB, Lee KS, Daly LA, Forbush KA, Lau HT, Golkowski M, McKnight GS, Breault DT, Lefrançois-Martinez AM, Martinez A, Eyers CE, Baird GS, Ong SE, Smith FD, Eyers PA, Scott JD. Omar MH, et al. Among authors: daly la. Cell Rep. 2022 Jul 12;40(2):111073. doi: 10.1016/j.celrep.2022.111073. Cell Rep. 2022. PMID: 35830806 Free PMC article.
Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2.
Byrne DP, Shrestha S, Daly LA, Marensi V, Ramakrishnan K, Eyers CE, Kannan N, Eyers PA. Byrne DP, et al. Among authors: daly la. Biochem J. 2023 Jan 31;480(2):141-160. doi: 10.1042/BCJ20220474. Biochem J. 2023. PMID: 36520605 Free PMC article.
Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases.
Venkat A, Watterson G, Byrne DP, O'Boyle B, Shrestha S, Gravel N, Fairweather EE, Daly LA, Bunn C, Yeung W, Aggarwal I, Katiyar S, Eyers CE, Eyers PA, Kannan N. Venkat A, et al. Among authors: daly la. bioRxiv [Preprint]. 2023 Jul 18:2023.03.29.534689. doi: 10.1101/2023.03.29.534689. bioRxiv. 2023. Update in: Elife. 2023 Oct 26;12:RP87958. doi: 10.7554/eLife.87958. PMID: 37034755 Free PMC article. Updated. Preprint.
20 results