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A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism.
Catrysse L, Maes B, Mehrotra P, Martens A, Hoste E, Martens L, Maueröder C, Remmerie A, Bujko A, Slowicka K, Sze M, Vikkula H, Ghesquière B, Scott CL, Saeys Y, van de Sluis B, Ravichandran K, Janssens S, van Loo G. Catrysse L, et al. Among authors: hoste e. Cell Rep. 2021 Sep 21;36(12):109748. doi: 10.1016/j.celrep.2021.109748. Cell Rep. 2021. PMID: 34551300 Free article.
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.
Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Vande Walle L, Jordao MJC, Sze M, Vikkula HK, Demeestere D, Van Imschoot G, Scott CL, Hoste E, Gonçalves A, Guilliams M, Lippens S, Libert C, Vandenbroucke RE, Kim KW, Jung S, Callaerts-Vegh Z, Callaerts P, de Wit J, Lamkanfi M, Prinz M, van Loo G. Voet S, et al. Among authors: hoste e. Nat Commun. 2018 May 23;9(1):2036. doi: 10.1038/s41467-018-04376-5. Nat Commun. 2018. PMID: 29789522 Free PMC article.
Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation.
Hoste E, Maueröder C, van Hove L, Catrysse L, Vikkula HK, Sze M, Maes B, Karjosukarso D, Martens L, Gonçalves A, Parthoens E, Roelandt R, Declercq W, Fuentes I, Palisson F, Gonzalez S, Salas-Alanis JC, Boon L, Huebener P, Mulder KW, Ravichandran K, Saeys Y, Schwabe RF, van Loo G. Hoste E, et al. Cell Rep. 2019 Nov 26;29(9):2689-2701.e4. doi: 10.1016/j.celrep.2019.10.104. Cell Rep. 2019. PMID: 31775038 Free article.
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Verboom L, Martens A, Priem D, Hoste E, Sze M, Vikkula H, Van Hove L, Voet S, Roels J, Maelfait J, Bongiovanni L, de Bruin A, Scott CL, Saeys Y, Pasparakis M, Bertrand MJM, van Loo G. Verboom L, et al. Among authors: hoste e. Cell Rep. 2020 Feb 18;30(7):2237-2247.e6. doi: 10.1016/j.celrep.2020.01.028. Cell Rep. 2020. PMID: 32075762 Free article.
Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities.
Martens A, Priem D, Hoste E, Vetters J, Rennen S, Catrysse L, Voet S, Deelen L, Sze M, Vikkula H, Slowicka K, Hochepied T, Iliaki K, Wullaert A, Janssens S, Lamkanfi M, Beyaert R, Armaka M, Bertrand MJM, van Loo G. Martens A, et al. Among authors: hoste e. Nat Immunol. 2020 Apr;21(4):381-387. doi: 10.1038/s41590-020-0621-9. Epub 2020 Mar 16. Nat Immunol. 2020. PMID: 32205881
Fibrotic enzymes modulate wound-induced skin tumorigenesis.
Van Hove L, Lecomte K, Roels J, Vandamme N, Vikkula HK, Hoorens I, Ongenae K, Hochepied T, Donati G, Saeys Y, Quist SR, Watt FM, van Loo G, Hoste E. Van Hove L, et al. Among authors: hoste e. EMBO Rep. 2021 May 5;22(5):e51573. doi: 10.15252/embr.202051573. Epub 2021 Mar 29. EMBO Rep. 2021. PMID: 33780134 Free PMC article.
OTULIN in NF-κB signaling, cell death, and disease.
Verboom L, Hoste E, van Loo G. Verboom L, et al. Among authors: hoste e. Trends Immunol. 2021 Jul;42(7):590-603. doi: 10.1016/j.it.2021.05.003. Epub 2021 May 29. Trends Immunol. 2021. PMID: 34074601 Review.
Zeb2 drives invasive and microbiota-dependent colon carcinoma.
Slowicka K, Petta I, Blancke G, Hoste E, Dumas E, Sze M, Vikkula H, Radaelli E, Haigh JJ, Jonckheere S, Taminau J, Vandamme N, Wullaert A, Tulchinsky E, Nittner D, Van Vlierberghe P, De Hertogh G, Baldin P, Etlioglu E, Wirapati P, Boon L, Lambrecht BN, Callewaert C, Tejpar S, Goossens S, Berx G, Vereecke L, van Loo G. Slowicka K, et al. Among authors: hoste e. Nat Cancer. 2020 Jun;1(6):620-634. doi: 10.1038/s43018-020-0070-2. Epub 2020 Jun 15. Nat Cancer. 2020. PMID: 35121975
Publisher Correction: Zeb2 drives invasive and microbiota-dependent colon carcinoma.
Slowicka K, Petta I, Blancke G, Hoste E, Dumas E, Sze M, Vikkula H, Radaelli E, Haigh JJ, Jonckheere S, Taminau J, Vandamme N, Wullaert A, Tulchinsky E, Nittner D, Van Vlierberghe P, De Hertogh G, Baldin P, Etlioglu E, Wirapati P, Boon L, Lambrecht BN, Callewaert C, Tejpar S, Goossens S, Berx G, Vereecke L, van Loo G. Slowicka K, et al. Among authors: hoste e. Nat Cancer. 2020 Jul;1(7):750. doi: 10.1038/s43018-020-0097-4. Nat Cancer. 2020. PMID: 35122045 No abstract available.
336 results