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Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors.
Abdul-Hay SO, Bannister TD, Wang H, Cameron MD, Caulfield TR, Masson A, Bertrand J, Howard EA, McGuire MP, Crisafulli U, Rosenberry TR, Topper CL, Thompson CR, Schürer SC, Madoux F, Hodder P, Leissring MA. Abdul-Hay SO, et al. Among authors: leissring ma. ACS Chem Biol. 2015 Dec 18;10(12):2716-24. doi: 10.1021/acschembio.5b00334. Epub 2015 Sep 30. ACS Chem Biol. 2015. PMID: 26398879 Free PMC article.
Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice.
Villa-Pérez P, Merino B, Fernández-Díaz CM, Cidad P, Lobatón CD, Moreno A, Muturi HT, Ghadieh HE, Najjar SM, Leissring MA, Cózar-Castellano I, Perdomo G. Villa-Pérez P, et al. Among authors: leissring ma. Metabolism. 2018 Nov;88:1-11. doi: 10.1016/j.metabol.2018.08.001. Epub 2018 Aug 8. Metabolism. 2018. PMID: 30098324 Free PMC article.
Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity.
Fernández-Díaz CM, Merino B, López-Acosta JF, Cidad P, de la Fuente MA, Lobatón CD, Moreno A, Leissring MA, Perdomo G, Cózar-Castellano I. Fernández-Díaz CM, et al. Among authors: leissring ma. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E805-E819. doi: 10.1152/ajpendo.00040.2019. Epub 2019 Sep 3. Am J Physiol Endocrinol Metab. 2019. PMID: 31479304 Free PMC article.
Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme.
González-Casimiro CM, Merino B, Casanueva-Álvarez E, Postigo-Casado T, Cámara-Torres P, Fernández-Díaz CM, Leissring MA, Cózar-Castellano I, Perdomo G. González-Casimiro CM, et al. Among authors: leissring ma. Biomedicines. 2021 Jan 17;9(1):86. doi: 10.3390/biomedicines9010086. Biomedicines. 2021. PMID: 33477364 Free PMC article. Review.
Targeting Insulin-Degrading Enzyme in Insulin Clearance.
Leissring MA, González-Casimiro CM, Merino B, Suire CN, Perdomo G. Leissring MA, et al. Int J Mol Sci. 2021 Feb 24;22(5):2235. doi: 10.3390/ijms22052235. Int J Mol Sci. 2021. PMID: 33668109 Free PMC article. Review.
66 results