Parrott N - Search Results

1

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates.

Reddy MB, Bolger MB, Fraczkiewicz G, Del Frari L, Luo L, Lukacova V, Mitra A, Macwan JS, Mullin JM, Parrott N, Heikkinen AT. Reddy MB, et al. Among authors: parrott n. Pharmaceutics. 2021 Aug 24;13(9):1325. doi: 10.3390/pharmaceutics13091325. Pharmaceutics. 2021. PMID: 34575401 Free PMC article. Review.

2

Challenges and opportunities with modelling and simulation in drug discovery and drug development.

Lavé T, Parrott N, Grimm HP, Fleury A, Reddy M. Lavé T, et al. Among authors: parrott n. Xenobiotica. 2007 Oct-Nov;37(10-11):1295-310. doi: 10.1080/00498250701534885. Xenobiotica. 2007. PMID: 17968746

3

Applications of physiologically based absorption models in drug discovery and development.

Parrott N, Lave T. Parrott N, et al. Mol Pharm. 2008 Sep-Oct;5(5):760-75. doi: 10.1021/mp8000155. Epub 2008 Jun 12. Mol Pharm. 2008. PMID: 18547054

4

Predicting pharmacokinetics of drugs using physiologically based modeling--application to food effects.

Parrott N, Lukacova V, Fraczkiewicz G, Bolger MB. Parrott N, et al. AAPS J. 2009 Mar;11(1):45-53. doi: 10.1208/s12248-008-9079-7. Epub 2009 Jan 29. AAPS J. 2009. PMID: 19184451 Free PMC article. Review.

5

Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.

Heikkinen AT, Friedlein A, Lamerz J, Jakob P, Cutler P, Fowler S, Williamson T, Tolando R, Lave T, Parrott N. Heikkinen AT, et al. Among authors: parrott n. Pharm Res. 2012 Jul;29(7):1832-42. doi: 10.1007/s11095-012-0707-7. Epub 2012 Feb 22. Pharm Res. 2012. PMID: 22354837

6

Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - an evaluation and case study using GastroPlus.

Heikkinen AT, Baneyx G, Caruso A, Parrott N. Heikkinen AT, et al. Among authors: parrott n. Eur J Pharm Sci. 2012 Sep 29;47(2):375-86. doi: 10.1016/j.ejps.2012.06.013. Epub 2012 Jul 1. Eur J Pharm Sci. 2012. PMID: 22759901

7

In vitro to in vivo extrapolation and physiologically based modeling of cytochrome P450 mediated metabolism in beagle dog gut wall and liver.

Heikkinen AT, Fowler S, Gray L, Li J, Peng Y, Yadava P, Railkar A, Parrott N. Heikkinen AT, et al. Among authors: parrott n. Mol Pharm. 2013 Apr 1;10(4):1388-99. doi: 10.1021/mp300692k. Epub 2013 Mar 13. Mol Pharm. 2013. PMID: 23438212

8

Applications of a 7-day Caco-2 cell model in drug discovery and development.

Peng Y, Yadava P, Heikkinen AT, Parrott N, Railkar A. Peng Y, et al. Among authors: parrott n. Eur J Pharm Sci. 2014 Jun 2;56:120-30. doi: 10.1016/j.ejps.2014.02.008. Epub 2014 Feb 24. Eur J Pharm Sci. 2014. PMID: 24576578

9

Quantitative ADME proteomics - CYP and UGT enzymes in the Beagle dog liver and intestine.

Heikkinen AT, Friedlein A, Matondo M, Hatley OJ, Petsalo A, Juvonen R, Galetin A, Rostami-Hodjegan A, Aebersold R, Lamerz J, Dunkley T, Cutler P, Parrott N. Heikkinen AT, et al. Among authors: parrott n. Pharm Res. 2015 Jan;32(1):74-90. doi: 10.1007/s11095-014-1446-8. Epub 2014 Jul 18. Pharm Res. 2015. PMID: 25033762

10

The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development.

Heikkinen AT, Lignet F, Cutler P, Parrott N. Heikkinen AT, et al. Among authors: parrott n. Proteomics Clin Appl. 2015 Aug;9(7-8):732-44. doi: 10.1002/prca.201400147. Epub 2015 Apr 13. Proteomics Clin Appl. 2015. PMID: 25676057 Review.

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