Chan KF - Search Results

1

Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).

Wong ILK, Zhu X, Chan KF, Liu Z, Chan CF, Chow TS, Chong TC, Law MC, Cui J, Chow LMC, Chan TH. Wong ILK, et al. Among authors: chan kf, chan th, chan cf. J Med Chem. 2021 Oct 14;64(19):14311-14331. doi: 10.1021/acs.jmedchem.1c00779. Epub 2021 Oct 4. J Med Chem. 2021. PMID: 34606270

2

Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.

Chan KF, Zhao Y, Burkett BA, Wong IL, Chow LM, Chan TH. Chan KF, et al. Among authors: chan th. J Med Chem. 2006 Nov 16;49(23):6742-59. doi: 10.1021/jm060593+. J Med Chem. 2006. PMID: 17154505

3

Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania.

Wong IL, Chan KF, Burkett BA, Zhao Y, Chai Y, Sun H, Chan TH, Chow LM. Wong IL, et al. Among authors: chan kf, chan th. Antimicrob Agents Chemother. 2007 Mar;51(3):930-40. doi: 10.1128/AAC.00998-06. Epub 2006 Dec 28. Antimicrob Agents Chemother. 2007. PMID: 17194831 Free PMC article.

4

Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships.

Chan KF, Zhao Y, Chow TW, Yan CS, Ma DL, Burkett BA, Wong IL, Chow LM, Chan TH. Chan KF, et al. Among authors: chan th. ChemMedChem. 2009 Apr;4(4):594-614. doi: 10.1002/cmdc.200800413. ChemMedChem. 2009. PMID: 19288491

5

Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania.

Wong IL, Chan KF, Zhao Y, Chan TH, Chow LM. Wong IL, et al. Among authors: chan kf, chan th. J Antimicrob Chemother. 2009 Jun;63(6):1179-90. doi: 10.1093/jac/dkp130. Epub 2009 Apr 17. J Antimicrob Chemother. 2009. PMID: 19377065

6

Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.

Wong IL, Chan KF, Tsang KH, Lam CY, Zhao Y, Chan TH, Chow LM. Wong IL, et al. Among authors: chan kf, chan th. J Med Chem. 2009 Sep 10;52(17):5311-22. doi: 10.1021/jm900194w. J Med Chem. 2009. PMID: 19725578

7

Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.

Chan KF, Wong IL, Kan JW, Yan CS, Chow LM, Chan TH. Chan KF, et al. Among authors: chan th. J Med Chem. 2012 Mar 8;55(5):1999-2014. doi: 10.1021/jm201121b. Epub 2012 Feb 22. J Med Chem. 2012. PMID: 22320402

8

Flavonoid dimers as novel, potent antileishmanial agents.

Wong IL, Chan KF, Chan TH, Chow LM. Wong IL, et al. Among authors: chan kf, chan th. J Med Chem. 2012 Oct 25;55(20):8891-902. doi: 10.1021/jm301172v. Epub 2012 Oct 3. J Med Chem. 2012. PMID: 22989363

9

In vitro and in vivo efficacy of novel flavonoid dimers against cutaneous leishmaniasis.

Wong IL, Chan KF, Chen YF, Lun ZR, Chan TH, Chow LM. Wong IL, et al. Among authors: chan kf, chan th. Antimicrob Agents Chemother. 2014 Jun;58(6):3379-88. doi: 10.1128/AAC.02425-13. Epub 2014 Mar 31. Antimicrob Agents Chemother. 2014. PMID: 24687505 Free PMC article.

10

A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo.

Yan CS, Wong IL, Chan KF, Kan JW, Chong TC, Law MC, Zhao Y, Chan SW, Chan TH, Chow LM. Yan CS, et al. Among authors: chan kf, chan sw, chan th. Mol Pharm. 2015 Oct 5;12(10):3507-17. doi: 10.1021/mp500770e. Epub 2015 Aug 27. Mol Pharm. 2015. PMID: 26291333

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