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Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.
Schmidt O, Nehls N, Prexler C, von Heyking K, Groll T, Pardon K, Garcia HD, Hensel T, Gürgen D, Henssen AG, Eggert A, Steiger K, Burdach S, Richter GHS. Schmidt O, et al. Among authors: henssen ag. J Exp Clin Cancer Res. 2021 Oct 15;40(1):322. doi: 10.1186/s13046-021-02125-z. J Exp Clin Cancer Res. 2021. PMID: 34654445 Free PMC article.
Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
Pearson ADJ, Federico S, Gatz SA, Ortiz M, Lesa G, Scobie N, Gounaris I, Weiner SL, Weigel B, Unger TJ, Stewart E, Smith M, Slotkin EK, Reaman G, Pappo A, Nysom K, Norga K, McDonough J, Marshall LV, Ludwinski D, Ligas F, Karres D, Kool M, Horner TJ, Henssen A, Heenen D, Hawkins DS, Gore L, Bender JG, Galluzzo S, Fox E, de Rojas T, Davies BR, Chakrabarti J, Carmichael J, Bradford D, Blanc P, Bernardi R, Benchetrit S, Akindele K, Vassal G. Pearson ADJ, et al. Eur J Cancer. 2023 Sep;190:112950. doi: 10.1016/j.ejca.2023.112950. Epub 2023 Jun 21. Eur J Cancer. 2023. PMID: 37441939 Free article. Review.
Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.
Henssen A, Althoff K, Odersky A, Beckers A, Koche R, Speleman F, Schäfers S, Bell E, Nortmeyer M, Westermann F, De Preter K, Florin A, Heukamp L, Spruessel A, Astrahanseff K, Lindner S, Sadowski N, Schramm A, Astorgues-Xerri L, Riveiro ME, Eggert A, Cvitkovic E, Schulte JH. Henssen A, et al. Clin Cancer Res. 2016 May 15;22(10):2470-81. doi: 10.1158/1078-0432.CCR-15-1449. Epub 2015 Dec 2. Clin Cancer Res. 2016. PMID: 26631615
Targeting tachykinin receptors in neuroblastoma.
Henssen AG, Odersky A, Szymansky A, Seiler M, Althoff K, Beckers A, Speleman F, Schäfers S, De Preter K, Astrahanseff K, Struck J, Schramm A, Eggert A, Bergmann A, Schulte JH. Henssen AG, et al. Oncotarget. 2017 Jan 3;8(1):430-443. doi: 10.18632/oncotarget.13440. Oncotarget. 2017. PMID: 27888795 Free PMC article.
Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A. Henssen AG, et al. Sci Transl Med. 2017 Nov 1;9(414):eaam9078. doi: 10.1126/scitranslmed.aam9078. Sci Transl Med. 2017. PMID: 29093183 Free PMC article.
Reflection of neuroblastoma intratumor heterogeneity in the new OHC-NB1 disease model.
Thole TM, Toedling J, Sprüssel A, Pfeil S, Savelyeva L, Capper D, Messerschmidt C, Beule D, Groeneveld-Krentz S, Eckert C, Gambara G, Henssen AG, Finkler S, Schulte JH, Sieber A, Bluethgen N, Regenbrecht CRA, Künkele A, Lodrini M, Eggert A, Deubzer HE. Thole TM, et al. Among authors: henssen ag. Int J Cancer. 2020 Feb 15;146(4):1031-1041. doi: 10.1002/ijc.32572. Epub 2019 Aug 1. Int J Cancer. 2020. PMID: 31304977
Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors.
Timme N, Han Y, Liu S, Yosief HO, García HD, Bei Y, Klironomos F, MacArthur IC, Szymansky A, von Stebut J, Bardinet V, Dohna C, Künkele A, Rolff J, Hundsdörfer P, Lissat A, Seifert G, Eggert A, Schulte JH, Zhang W, Henssen AG. Timme N, et al. Among authors: henssen ag. Transl Oncol. 2020 Feb;13(2):221-232. doi: 10.1016/j.tranon.2019.09.013. Epub 2019 Dec 21. Transl Oncol. 2020. PMID: 31869746 Free PMC article.
70 results