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Spatial transcriptomics reveals a role for sensory nerves in preserving cranial suture patency through modulation of BMP/TGF-β signaling.
Tower RJ, Li Z, Cheng YH, Wang XW, Rajbhandari L, Zhang Q, Negri S, Uytingco CR, Venkatesan A, Zhou FQ, Cahan P, James AW, Clemens TL. Tower RJ, et al. Among authors: clemens tl. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2103087118. doi: 10.1073/pnas.2103087118. Proc Natl Acad Sci U S A. 2021. PMID: 34663698 Free PMC article.
NGF-p75 signaling coordinates skeletal cell migration during bone repair.
Xu J, Li Z, Tower RJ, Negri S, Wang Y, Meyers CA, Sono T, Qin Q, Lu A, Xing X, McCarthy EF, Clemens TL, James AW. Xu J, et al. Among authors: clemens tl. Sci Adv. 2022 Mar 18;8(11):eabl5716. doi: 10.1126/sciadv.abl5716. Epub 2022 Mar 18. Sci Adv. 2022. PMID: 35302859 Free PMC article.
Fracture repair requires TrkA signaling by skeletal sensory nerves.
Li Z, Meyers CA, Chang L, Lee S, Li Z, Tomlinson R, Hoke A, Clemens TL, James AW. Li Z, et al. Among authors: clemens tl. J Clin Invest. 2019 Dec 2;129(12):5137-5150. doi: 10.1172/JCI128428. J Clin Invest. 2019. PMID: 31638597 Free PMC article.
A Neurotrophic Mechanism Directs Sensory Nerve Transit in Cranial Bone.
Meyers CA, Lee S, Sono T, Xu J, Negri S, Tian Y, Wang Y, Li Z, Miller S, Chang L, Gao Y, Minichiello L, Clemens TL, James AW. Meyers CA, et al. Among authors: clemens tl. Cell Rep. 2020 May 26;31(8):107696. doi: 10.1016/j.celrep.2020.107696. Cell Rep. 2020. PMID: 32460020 Free PMC article.
NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma.
Lee S, Hwang C, Marini S, Tower RJ, Qin Q, Negri S, Pagani CA, Sun Y, Stepien DM, Sorkin M, Kubiak CA, Visser ND, Meyers CA, Wang Y, Rasheed HA, Xu J, Miller S, Huber AK, Minichiello L, Cederna PS, Kemp SWP, Clemens TL, James AW, Levi B. Lee S, et al. Among authors: clemens tl. Nat Commun. 2021 Aug 16;12(1):4939. doi: 10.1038/s41467-021-25143-z. Nat Commun. 2021. PMID: 34400627 Free PMC article.
222 results