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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.
Imaide S, Riching KM, Makukhin N, Vetma V, Whitworth C, Hughes SJ, Trainor N, Mahan SD, Murphy N, Cowan AD, Chan KH, Craigon C, Testa A, Maniaci C, Urh M, Daniels DL, Ciulli A. Imaide S, et al. Among authors: chan kh. Nat Chem Biol. 2021 Nov;17(11):1157-1167. doi: 10.1038/s41589-021-00878-4. Epub 2021 Oct 21. Nat Chem Biol. 2021. PMID: 34675414 Free PMC article.
3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation.
Testa A, Lucas X, Castro GV, Chan KH, Wright JE, Runcie AC, Gadd MS, Harrison WTA, Ko EJ, Fletcher D, Ciulli A. Testa A, et al. Among authors: chan kh. J Am Chem Soc. 2018 Jul 25;140(29):9299-9313. doi: 10.1021/jacs.8b05807. Epub 2018 Jul 12. J Am Chem Soc. 2018. PMID: 29949369 Free PMC article.
Correction to "3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation".
Testa A, Lucas X, Castro GV, Chan KH, Wright JE, Runcie AC, Gadd MS, Harrison WTA, Ko EJ, Fletcher D, Ciulli A. Testa A, et al. Among authors: chan kh. J Am Chem Soc. 2019 May 8;141(18):7644. doi: 10.1021/jacs.9b03833. Epub 2019 Apr 24. J Am Chem Soc. 2019. PMID: 31017404 Free PMC article. No abstract available.
Understanding and Improving the Membrane Permeability of VH032-Based PROTACs.
Klein VG, Townsend CE, Testa A, Zengerle M, Maniaci C, Hughes SJ, Chan KH, Ciulli A, Lokey RS. Klein VG, et al. Among authors: chan kh. ACS Med Chem Lett. 2020 Jul 30;11(9):1732-1738. doi: 10.1021/acsmedchemlett.0c00265. eCollection 2020 Sep 10. ACS Med Chem Lett. 2020. PMID: 32939229 Free PMC article.
1,448 results