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p21 produces a bioactive secretome that places stressed cells under immunosurveillance.
Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. Sturmlechner I, et al. Science. 2021 Oct 29;374(6567):eabb3420. doi: 10.1126/science.abb3420. Epub 2021 Oct 29. Science. 2021. PMID: 34709885 Free PMC article.
Cellular senescence in renal ageing and disease.
Sturmlechner I, Durik M, Sieben CJ, Baker DJ, van Deursen JM. Sturmlechner I, et al. Nat Rev Nephrol. 2017 Feb;13(2):77-89. doi: 10.1038/nrneph.2016.183. Epub 2016 Dec 28. Nat Rev Nephrol. 2017. PMID: 28029153 Review.
Two-Step Senescence-Focused Cancer Therapies.
Sieben CJ, Sturmlechner I, van de Sluis B, van Deursen JM. Sieben CJ, et al. Among authors: sturmlechner i. Trends Cell Biol. 2018 Sep;28(9):723-737. doi: 10.1016/j.tcb.2018.04.006. Epub 2018 May 17. Trends Cell Biol. 2018. PMID: 29776716 Free PMC article. Review.
Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice.
Aziz K, Limzerwala JF, Sturmlechner I, Hurley E, Zhang C, Jeganathan KB, Nelson G, Bronk S, Fierro Velasco RO, van Deursen EJ, O'Brien DR, Kocher JA, Youssef SA, van Ree JH, de Bruin A, van den Bos H, Spierings DCJ, Foijer F, van de Sluis B, Roberts LR, Gores GJ, Li H, van Deursen JM. Aziz K, et al. Among authors: sturmlechner i. Gastroenterology. 2019 Jul;157(1):210-226.e12. doi: 10.1053/j.gastro.2019.03.016. Epub 2019 Mar 13. Gastroenterology. 2019. PMID: 30878468 Free PMC article.
Senescent cells in the development of cardiometabolic disease.
Postmus AC, Sturmlechner I, Jonker JW, van Deursen JM, van de Sluis B, Kruit JK. Postmus AC, et al. Among authors: sturmlechner i. Curr Opin Lipidol. 2019 Jun;30(3):177-185. doi: 10.1097/MOL.0000000000000602. Curr Opin Lipidol. 2019. PMID: 30913069 Free PMC article. Review.
FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer.
Limzerwala JF, Jeganathan KB, Kloeber JA, Davies BA, Zhang C, Sturmlechner I, Zhong J, Fierro Velasco R, Fields AP, Yuan Y, Baker DJ, Zhou D, Li H, Katzmann DJ, van Deursen JM. Limzerwala JF, et al. Among authors: sturmlechner i. Nat Cancer. 2020 Oct;1(10):1010-1024. doi: 10.1038/s43018-020-00116-1. Epub 2020 Oct 12. Nat Cancer. 2020. PMID: 34841254 Free PMC article.
28 results