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Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study.
McCarthy JS, Yalkinoglu Ö, Odedra A, Webster R, Oeuvray C, Tappert A, Bezuidenhout D, Giddins MJ, Dhingra SK, Fidock DA, Marquart L, Webb L, Yin X, Khandelwal A, Bagchus WM. McCarthy JS, et al. Among authors: giddins mj. Lancet Infect Dis. 2021 Dec;21(12):1713-1724. doi: 10.1016/S1473-3099(21)00252-8. Epub 2021 Oct 26. Lancet Infect Dis. 2021. PMID: 34715032 Free PMC article. Clinical Trial.
Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor.
Rottmann M, Jonat B, Gumpp C, Dhingra SK, Giddins MJ, Yin X, Badolo L, Greco B, Fidock DA, Oeuvray C, Spangenberg T. Rottmann M, et al. Among authors: giddins mj. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02181-19. doi: 10.1128/AAC.02181-19. Print 2020 Mar 24. Antimicrob Agents Chemother. 2020. PMID: 32041711 Free PMC article.
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.
Vanaerschot M, Murithi JM, Pasaje CFA, Ghidelli-Disse S, Dwomoh L, Bird M, Spottiswoode N, Mittal N, Arendse LB, Owen ES, Wicht KJ, Siciliano G, Bösche M, Yeo T, Kumar TRS, Mok S, Carpenter EF, Giddins MJ, Sanz O, Ottilie S, Alano P, Chibale K, Llinás M, Uhlemann AC, Delves M, Tobin AB, Doerig C, Winzeler EA, Lee MCS, Niles JC, Fidock DA. Vanaerschot M, et al. Among authors: giddins mj. Cell Chem Biol. 2020 Jul 16;27(7):806-816.e8. doi: 10.1016/j.chembiol.2020.04.001. Epub 2020 Apr 30. Cell Chem Biol. 2020. PMID: 32359426 Free PMC article.
Genomic Surveillance Reveals Diversity of Multidrug-Resistant Organism Colonization and Infection: A Prospective Cohort Study in Liver Transplant Recipients.
Macesic N, Gomez-Simmonds A, Sullivan SB, Giddins MJ, Ferguson SA, Korakavi G, Leeds D, Park S, Shim K, Sowash MG, Hofbauer M, Finkel R, Hu Y, West J, Toussaint NC, Greendyke WG, Miko BA, Pereira MR, Whittier S, Verna EC, Uhlemann AC. Macesic N, et al. Among authors: giddins mj. Clin Infect Dis. 2018 Aug 31;67(6):905-912. doi: 10.1093/cid/ciy199. Clin Infect Dis. 2018. PMID: 29718144 Free PMC article.
Escherichia coli Harboring mcr-1 in a Cluster of Liver Transplant Recipients: Detection through Active Surveillance and Whole-Genome Sequencing.
Macesic N, Khan S, Giddins MJ, Freedberg DE, Whittier S, Green DA, Furuya EY, Verna EC, Annavajhala MK, Gomez-Simmonds A, Uhlemann AC. Macesic N, et al. Among authors: giddins mj. Antimicrob Agents Chemother. 2019 May 24;63(6):e02680-18. doi: 10.1128/AAC.02680-18. Print 2019 Jun. Antimicrob Agents Chemother. 2019. PMID: 30962343 Free PMC article.
Piperacillin-Tazobactam versus Other Antibacterial Agents for Treatment of Bloodstream Infections Due to AmpC β-Lactamase-Producing Enterobacteriaceae.
Cheng L, Nelson BC, Mehta M, Seval N, Park S, Giddins MJ, Shi Q, Whittier S, Gomez-Simmonds A, Uhlemann AC. Cheng L, et al. Among authors: giddins mj. Antimicrob Agents Chemother. 2017 May 24;61(6):e00276-17. doi: 10.1128/AAC.00276-17. Print 2017 Jun. Antimicrob Agents Chemother. 2017. PMID: 28320724 Free PMC article.
17 results