Khandelwal A - Search Results

1

Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study.

McCarthy JS, Yalkinoglu Ö, Odedra A, Webster R, Oeuvray C, Tappert A, Bezuidenhout D, Giddins MJ, Dhingra SK, Fidock DA, Marquart L, Webb L, Yin X, Khandelwal A, Bagchus WM. McCarthy JS, et al. Among authors: khandelwal a. Lancet Infect Dis. 2021 Dec;21(12):1713-1724. doi: 10.1016/S1473-3099(21)00252-8. Epub 2021 Oct 26. Lancet Infect Dis. 2021. PMID: 34715032 Free PMC article. Clinical Trial.

2

Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside.

Khandelwal A, Arez F, Alves PM, Badolo L, Brito C, Fischli C, Fontinha D, Oeuvray C, Prudêncio M, Rottmann M, Wilkins J, Yalkinoglu Ö, Bagchus WM, Spangenberg T. Khandelwal A, et al. Malar J. 2022 May 15;21(1):151. doi: 10.1186/s12936-022-04171-0. Malar J. 2022. PMID: 35570264 Free PMC article.

3

Semi-mechanistic population pharmacokinetic/pharmacodynamic modeling of a Plasmodium elongation factor 2 inhibitor cabamiquine for prevention and cure of malaria.

Courlet P, Wilkins JJ, Oeuvray C, Gao W, Khandelwal A. Courlet P, et al. Among authors: khandelwal a. Antimicrob Agents Chemother. 2023 Dec 14;67(12):e0089123. doi: 10.1128/aac.00891-23. Epub 2023 Nov 15. Antimicrob Agents Chemother. 2023. PMID: 37966273 Free PMC article.

4

Population Pharmacokinetic Analysis of Bintrafusp Alfa in Different Cancer Types.

Wilkins JJ, Vugmeyster Y, Dussault I, Girard P, Khandelwal A. Wilkins JJ, et al. Among authors: khandelwal a. Adv Ther. 2019 Sep;36(9):2414-2433. doi: 10.1007/s12325-019-01018-0. Epub 2019 Jul 5. Adv Ther. 2019. PMID: 31278692

5

Avelumab Dose Selection for Clinical Studies in Pediatric Patients with Solid Tumors.

Vugmeyster Y, Grisic AM, Brockhaus B, Rueckert P, Ruisi M, Dai H, Khandelwal A. Vugmeyster Y, et al. Among authors: khandelwal a. Clin Pharmacokinet. 2022 Jul;61(7):985-995. doi: 10.1007/s40262-022-01111-8. Epub 2022 Apr 29. Clin Pharmacokinet. 2022. PMID: 35484319 Free PMC article.

6

Time-Varying Clearance and Impact of Disease State on the Pharmacokinetics of Avelumab in Merkel Cell Carcinoma and Urothelial Carcinoma.

Wilkins JJ, Brockhaus B, Dai H, Vugmeyster Y, White JT, Brar S, Bello CL, Neuteboom B, Wade JR, Girard P, Khandelwal A. Wilkins JJ, et al. Among authors: khandelwal a. CPT Pharmacometrics Syst Pharmacol. 2019 Jun;8(6):415-427. doi: 10.1002/psp4.12406. Epub 2019 Apr 25. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30980481 Free PMC article.

7

Selection of the Recommended Phase 2 Dose for Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1.

Vugmeyster Y, Wilkins J, Koenig A, El Bawab S, Dussault I, Ojalvo LS, De Banerjee S, Klopp-Schulze L, Khandelwal A. Vugmeyster Y, et al. Among authors: khandelwal a. Clin Pharmacol Ther. 2020 Sep;108(3):566-574. doi: 10.1002/cpt.1776. Epub 2020 Mar 3. Clin Pharmacol Ther. 2020. PMID: 31955412 Free PMC article.

8

Applying Modeling and Simulations for Rational Dose Selection of Novel Toll-Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need.

Klopp-Schulze L, Shaw JV, Dong JQ, Khandelwal A, Vazquez-Mateo C, Goteti K. Klopp-Schulze L, et al. Among authors: khandelwal a. Clin Pharmacol Ther. 2022 Aug;112(2):297-306. doi: 10.1002/cpt.2606. Epub 2022 May 21. Clin Pharmacol Ther. 2022. PMID: 35390178 Free PMC article. Clinical Trial.

9

Changing Body Weight-Based Dosing to a Flat Dose for Avelumab in Metastatic Merkel Cell and Advanced Urothelial Carcinoma.

Novakovic AM, Wilkins JJ, Dai H, Wade JR, Neuteboom B, Brar S, Bello CL, Girard P, Khandelwal A. Novakovic AM, et al. Among authors: khandelwal a. Clin Pharmacol Ther. 2020 Mar;107(3):588-596. doi: 10.1002/cpt.1645. Epub 2019 Nov 18. Clin Pharmacol Ther. 2020. PMID: 31553054 Free PMC article.

10

Semimechanistic Clearance Models of Oncology Biotherapeutics and Impact of Study Design: Cetuximab as a Case Study.

Grisic AM, Khandelwal A, Bertolino M, Huisinga W, Girard P, Kloft C. Grisic AM, et al. Among authors: khandelwal a. CPT Pharmacometrics Syst Pharmacol. 2020 Nov;9(11):628-638. doi: 10.1002/psp4.12558. Epub 2020 Oct 9. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 33015996 Free PMC article. Clinical Trial.

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