He S - Search Results

1

Structural simplification and bioisostere principle lead to Bis-benzodioxole-fibrate derivatives as potential hypolipidemic and hepatoprotective agents.

Xie Y, Liu J, Shi Y, Wang B, Wang X, Wang W, Sun M, Xu X, Cheng L, He S. Xie Y, et al. Among authors: he s. Bioorg Chem. 2021 Dec;117:105454. doi: 10.1016/j.bioorg.2021.105454. Epub 2021 Oct 26. Bioorg Chem. 2021. PMID: 34740054

2

Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase.

Chen W, Dong G, He S, Xu T, Wang X, Liu N, Zhang W, Miao C, Sheng C. Chen W, et al. Among authors: he s. Bioorg Med Chem Lett. 2016 Feb 1;26(3):765-768. doi: 10.1016/j.bmcl.2015.12.101. Epub 2015 Dec 29. Bioorg Med Chem Lett. 2016. PMID: 26755394

3

Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran-oxindole derivatives as potent p53-MDM2 inhibitors.

Ji C, Wang S, Chen S, He S, Jiang Y, Miao Z, Li J, Sheng C. Ji C, et al. Among authors: he s. Bioorg Med Chem. 2017 Oct 15;25(20):5268-5277. doi: 10.1016/j.bmc.2017.07.049. Epub 2017 Jul 28. Bioorg Med Chem. 2017. PMID: 28797774

4

Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA.

Fang K, Dong G, Wang H, He S, Wu S, Wang W, Sheng C. Fang K, et al. Among authors: he s. ChemMedChem. 2018 Jan 8;13(1):30-36. doi: 10.1002/cmdc.201700666. Epub 2017 Dec 18. ChemMedChem. 2018. PMID: 29205945

5

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors.

Fang K, Dong G, Li Y, He S, Wu Y, Wu S, Wang W, Sheng C. Fang K, et al. Among authors: he s. ACS Med Chem Lett. 2018 Mar 26;9(4):312-317. doi: 10.1021/acsmedchemlett.7b00487. eCollection 2018 Apr 12. ACS Med Chem Lett. 2018. PMID: 29670692 Free PMC article.

6

Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents.

He S, Dong G, Wu S, Fang K, Miao Z, Wang W, Sheng C. He S, et al. J Med Chem. 2018 Aug 23;61(16):7245-7260. doi: 10.1021/acs.jmedchem.8b00664. Epub 2018 Aug 9. J Med Chem. 2018. PMID: 30045621

7

Design, synthesis and biological evaluation of novel antitumor spirodihydrothiopyran-oxindole derivatives.

Liu W, Chen S, Zhang F, He S, Wang S, Sheng C. Liu W, et al. Among authors: he s. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1636-1642. doi: 10.1016/j.bmcl.2019.04.037. Epub 2019 Apr 26. Bioorg Med Chem Lett. 2019. PMID: 31047751

8

Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer.

He S, Dong G, Li Y, Wu S, Wang W, Sheng C. He S, et al. Angew Chem Int Ed Engl. 2020 Feb 17;59(8):3028-3032. doi: 10.1002/anie.201915896. Epub 2020 Jan 30. Angew Chem Int Ed Engl. 2020. PMID: 31943585

9

Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer.

He S, Ma J, Fang Y, Liu Y, Wu S, Dong G, Wang W, Sheng C. He S, et al. Acta Pharm Sin B. 2021 Jun;11(6):1617-1628. doi: 10.1016/j.apsb.2020.11.022. Epub 2020 Dec 2. Acta Pharm Sin B. 2021. PMID: 34221872 Free PMC article.

10

Optimization of clofibrate with O-desmethyl anetholtrithione lead to a novel hypolipidemia compound with hepatoprotective effect.

Liu H, Zhang P, Ge X, Wu Q, Han C, Zhang L, Hua Y, Zhang Y, Liu J, Shi Y, Wang B, Wang X, Wang W, Jiang Y, Zhang H, Deng C, Xie Y, Liu Y, He S. Liu H, et al. Among authors: he s. Bioorg Med Chem Lett. 2022 Sep 15;72:128844. doi: 10.1016/j.bmcl.2022.128844. Epub 2022 Jun 10. Bioorg Med Chem Lett. 2022. PMID: 35697180

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