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Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells.
Zhou L, Huntington K, Zhang S, Carlsen L, So EY, Parker C, Sahin I, Safran H, Kamle S, Lee CM, Lee CG, Elias JA, Campbell KS, Naik MT, Atwood WJ, Youssef E, Pachter JA, Navaraj A, Seyhan AA, Liang O, El-Deiry WS. Zhou L, et al. bioRxiv [Preprint]. 2020 Sep 2:2020.08.02.230839. doi: 10.1101/2020.08.02.230839. bioRxiv. 2020. PMID: 32793908 Free PMC article. Preprint.
MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection.
Zhou L, Huntington K, Zhang S, Carlsen L, So EY, Parker C, Sahin I, Safran H, Kamle S, Lee CM, Geun Lee C, A Elias J, S Campbell K, T Naik M, J Atwood W, Youssef E, A Pachter J, Navaraj A, A Seyhan A, Liang O, El-Deiry WS. Zhou L, et al. Oncotarget. 2020 Nov 17;11(46):4201-4223. doi: 10.18632/oncotarget.27799. eCollection 2020 Nov 17. Oncotarget. 2020. PMID: 33245731 Free PMC article.
Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19.
Kamle S, Ma B, He CH, Akosman B, Zhou Y, Lee CM, El-Deiry WS, Huntington K, Liang O, Machan JT, Kang MJ, Shin HJ, Mizoguchi E, Lee CG, Elias JA. Kamle S, et al. bioRxiv [Preprint]. 2021 Feb 16:2021.01.05.425478. doi: 10.1101/2021.01.05.425478. bioRxiv. 2021. Update in: JCI Insight. 2021 Nov 8;6(21):e148749. doi: 10.1172/jci.insight.148749 PMID: 33442679 Free PMC article. Updated. Preprint.
501 results