Laselva O - Search Results

1

Generation of functional ciliated cholangiocytes from human pluripotent stem cells.

Ogawa M, Jiang JX, Xia S, Yang D, Ding A, Laselva O, Hernandez M, Cui C, Higuchi Y, Suemizu H, Dorrell C, Grompe M, Bear CE, Ogawa S. Ogawa M, et al. Among authors: laselva o. Nat Commun. 2021 Nov 11;12(1):6504. doi: 10.1038/s41467-021-26764-0. Nat Commun. 2021. PMID: 34764255 Free PMC article.

2

The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain.

Laselva O, Molinski S, Casavola V, Bear CE. Laselva O, et al. Biochem Pharmacol. 2016 Nov 1;119:85-92. doi: 10.1016/j.bcp.2016.09.005. Epub 2016 Sep 8. Biochem Pharmacol. 2016. PMID: 27614011

3

Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue.

Molinski SV, Ahmadi S, Ip W, Ouyang H, Villella A, Miller JP, Lee PS, Kulleperuma K, Du K, Di Paola M, Eckford PD, Laselva O, Huan LJ, Wellhauser L, Li E, Ray PN, Pomès R, Moraes TJ, Gonska T, Ratjen F, Bear CE. Molinski SV, et al. Among authors: laselva o. EMBO Mol Med. 2017 Sep;9(9):1224-1243. doi: 10.15252/emmm.201607137. EMBO Mol Med. 2017. PMID: 28667089 Free PMC article.

4

Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site.

Molinski SV, Shahani VM, Subramanian AS, MacKinnon SS, Woollard G, Laforet M, Laselva O, Morayniss LD, Bear CE, Windemuth A. Molinski SV, et al. Among authors: laselva o. Proteins. 2018 Aug;86(8):833-843. doi: 10.1002/prot.25496. Epub 2018 Apr 10. Proteins. 2018. PMID: 29569753

5

Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains.

Laselva O, Molinski S, Casavola V, Bear CE. Laselva O, et al. Mol Pharmacol. 2018 Jun;93(6):612-618. doi: 10.1124/mol.118.111799. Epub 2018 Apr 4. Mol Pharmacol. 2018. PMID: 29618585

6

Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators.

Laselva O, Marzaro G, Vaccarin C, Lampronti I, Tamanini A, Lippi G, Gambari R, Cabrini G, Bear CE, Chilin A, Dechecchi MC. Laselva O, et al. Front Pharmacol. 2018 Jul 4;9:719. doi: 10.3389/fphar.2018.00719. eCollection 2018. Front Pharmacol. 2018. PMID: 30022950 Free PMC article.

7

Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).

Chin S, Ramjeesingh M, Hung M, Ereño-Oreba J, Cui H, Laselva O, Julien JP, Bear CE. Chin S, et al. Among authors: laselva o. Cells. 2019 Jul 31;8(8):804. doi: 10.3390/cells8080804. Cells. 2019. PMID: 31370288 Free PMC article.

8

ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel.

Wu YS, Jiang J, Ahmadi S, Lew A, Laselva O, Xia S, Bartlett C, Ip W, Wellhauser L, Ouyang H, Gonska T, Moraes TJ, Bear CE. Wu YS, et al. Among authors: laselva o. Mol Pharmacol. 2019 Oct;96(4):515-525. doi: 10.1124/mol.119.117143. Epub 2019 Aug 19. Mol Pharmacol. 2019. PMID: 31427400

9

Functional rescue of c.3846G>A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action.

Laselva O, Eckford PD, Bartlett C, Ouyang H, Gunawardena TN, Gonska T, Moraes TJ, Bear CE. Laselva O, et al. J Cyst Fibros. 2020 Sep;19(5):717-727. doi: 10.1016/j.jcf.2019.12.001. Epub 2019 Dec 9. J Cyst Fibros. 2020. PMID: 31831337 Free article.

10

Anti-Infectives Restore ORKAMBI^® Rescue of F508del-CFTR Function in Human Bronchial Epithelial Cells Infected with Clinical Strains of P. aeruginosa.

Laselva O, Stone TA, Bear CE, Deber CM. Laselva O, et al. Biomolecules. 2020 Feb 19;10(2):334. doi: 10.3390/biom10020334. Biomolecules. 2020. PMID: 32092967 Free PMC article.

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