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Finerenone Dose-Exposure-Response for the Primary Kidney Outcome in FIDELIO-DKD Phase III: Population Pharmacokinetic and Time-to-Event Analysis.
van den Berg P, Ruppert M, Mesic E, Snelder N, Seelmann A, Heinig R, Joseph A, Garmann D, Lippert J, Eissing T. van den Berg P, et al. Among authors: heinig r. Clin Pharmacokinet. 2022 Mar;61(3):439-450. doi: 10.1007/s40262-021-01082-2. Epub 2021 Nov 13. Clin Pharmacokinet. 2022. PMID: 34773606 Free PMC article. Clinical Trial.
Pharmacokinetics of the Novel, Selective, Non-steroidal Mineralocorticoid Receptor Antagonist Finerenone in Healthy Volunteers: Results from an Absolute Bioavailability Study and Drug-Drug Interaction Studies In Vitro and In Vivo.
Heinig R, Gerisch M, Engelen A, Nagelschmitz J, Loewen S. Heinig R, et al. Eur J Drug Metab Pharmacokinet. 2018 Dec;43(6):715-727. doi: 10.1007/s13318-018-0483-9. Eur J Drug Metab Pharmacokinet. 2018. PMID: 29779093 Clinical Trial.
Population Pharmacokinetic and Exposure-Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease.
Snelder N, Heinig R, Drenth HJ, Joseph A, Kolkhof P, Lippert J, Garmann D, Ploeger B, Eissing T. Snelder N, et al. Among authors: heinig r. Clin Pharmacokinet. 2020 Mar;59(3):359-370. doi: 10.1007/s40262-019-00820-x. Clin Pharmacokinet. 2020. PMID: 31583611 Free PMC article. Clinical Trial.
Determination of finerenone - a novel, selective, nonsteroidal mineralocorticoid receptor antagonist - in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study in venous and capillary human plasma.
Rohde G, Loewen S, Heinig R. Rohde G, et al. Among authors: heinig r. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 May 15;1172:122643. doi: 10.1016/j.jchromb.2021.122643. Epub 2021 Mar 5. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 33770684 Clinical Trial.
63 results