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Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report.
Cable J, Leonard JN, Lu TK, Xie Z, Chang MW, Fernández LÁ, Lora JM, Kaufman HL, Quintana FJ, Geiger R, F Lesser C, Lynch JP, Hava DL, Cornish VW, Lee GK, DiAndreth B, Fero M, Srivastava R, De Coster T, Roybal KT, Rackham OJL, Kiani S, Zhu I, Hernandez-Lopez RA, Guo T, Chen WCW. Cable J, et al. Among authors: lynch jp. Ann N Y Acad Sci. 2021 Dec;1506(1):98-117. doi: 10.1111/nyas.14710. Epub 2021 Nov 16. Ann N Y Acad Sci. 2021. PMID: 34786712 Review.
A host metabolite promotes Salmonella survival.
Lynch JP, Lesser CF. Lynch JP, et al. Science. 2021 Jan 22;371(6527):344-345. doi: 10.1126/science.abf8414. Science. 2021. PMID: 33479138 No abstract available.
In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli.
Srivastava R, González-Prieto C, Lynch JP, Muscolo M, Lin CY, Brown MA, Lemos L, Shrestha A, Osburne MS, Leong JM, Lesser CF. Srivastava R, et al. Among authors: lynch jp. bioRxiv [Preprint]. 2024 Jul 30:2024.07.30.605899. doi: 10.1101/2024.07.30.605899. bioRxiv. 2024. Update in: PNAS Nexus. 2024 Sep 02;3(9):pgae374. doi: 10.1093/pnasnexus/pgae374 PMID: 39131305 Free PMC article. Updated. Preprint.
Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut.
Lynch JP, González-Prieto C, Reeves AZ, Bae S, Powale U, Godbole NP, Tremblay JM, Schmidt FI, Ploegh HL, Kansra V, Glickman JN, Leong JM, Shoemaker CB, Garrett WS, Lesser CF. Lynch JP, et al. Cell Host Microbe. 2023 Apr 12;31(4):634-649.e8. doi: 10.1016/j.chom.2023.03.007. Epub 2023 Mar 31. Cell Host Microbe. 2023. PMID: 37003258 Free PMC article.
Root phenotypes for improved nitrogen capture.
Lynch JP, Galindo-Castañeda T, Schneider HM, Sidhu JS, Rangarajan H, York LM. Lynch JP, et al. Plant Soil. 2024;502(1-2):31-85. doi: 10.1007/s11104-023-06301-2. Epub 2023 Oct 4. Plant Soil. 2024. PMID: 39323575 Free PMC article. Review.
615 results