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Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models.
Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Singh S, et al. Among authors: nijhawan d. Sci Adv. 2021 Nov 19;7(47):eabj5405. doi: 10.1126/sciadv.abj5405. Epub 2021 Nov 17. Sci Adv. 2021. PMID: 34788094 Free PMC article.
The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α.
Han T, Goralski M, Capota E, Padrick SB, Kim J, Xie Y, Nijhawan D. Han T, et al. Among authors: nijhawan d. Nat Chem Biol. 2016 Jul;12(7):511-5. doi: 10.1038/nchembio.2082. Epub 2016 May 16. Nat Chem Biol. 2016. PMID: 27182663 Free PMC article.
Biomarkers for RBM39 degradation in acute myeloid leukemia.
Hsiehchen D, Goralski M, Kim J, Xie Y, Nijhawan D. Hsiehchen D, et al. Among authors: nijhawan d. Leukemia. 2020 Jul;34(7):1924-1928. doi: 10.1038/s41375-020-0729-9. Epub 2020 Feb 10. Leukemia. 2020. PMID: 32042080 Free PMC article. No abstract available.
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.
Nguyen TP, Fang M, Kim J, Wang B, Lin E, Khivansara V, Barrows N, Rivera-Cancel G, Goralski M, Cervantes CL, Xie S, Peterson JM, Povedano JM, Antczak MI, Posner BA, Harvey CJB, Naughton BT, McFadden DG, Ready JM, De Brabander JK, Nijhawan D. Nguyen TP, et al. Among authors: nijhawan d. Cell Chem Biol. 2023 Nov 16;30(11):1453-1467.e8. doi: 10.1016/j.chembiol.2023.07.017. Epub 2023 Aug 21. Cell Chem Biol. 2023. PMID: 37607550 Free PMC article.
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D. Theodoropoulos PC, et al. Among authors: nijhawan d. Nat Chem Biol. 2016 Apr;12(4):218-25. doi: 10.1038/nchembio.2016. Epub 2016 Feb 1. Nat Chem Biol. 2016. PMID: 26829472 Free PMC article.
39 results