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The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease.
Avolio E, Carrabba M, Milligan R, Kavanagh Williamson M, Beltrami AP, Gupta K, Elvers KT, Gamez M, Foster RR, Gillespie K, Hamilton F, Arnold D, Berger I, Davidson AD, Hill D, Caputo M, Madeddu P. Avolio E, et al. Among authors: gamez m. Clin Sci (Lond). 2021 Dec 22;135(24):2667-2689. doi: 10.1042/CS20210735. Clin Sci (Lond). 2021. PMID: 34807265 Free PMC article.
VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy.
Onions KL, Gamez M, Buckner NR, Baker SL, Betteridge KB, Desideri S, Dallyn BP, Ramnath RD, Neal CR, Farmer LK, Mathieson PW, Gnudi L, Alitalo K, Bates DO, Salmon AHJ, Welsh GI, Satchell SC, Foster RR. Onions KL, et al. Among authors: gamez m. Diabetes. 2019 Jan;68(1):172-187. doi: 10.2337/db18-0045. Epub 2018 Nov 2. Diabetes. 2019. PMID: 30389746
Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease.
Ramnath RD, Butler MJ, Newman G, Desideri S, Russell A, Lay AC, Neal CR, Qiu Y, Fawaz S, Onions KL, Gamez M, Crompton M, Michie C, Finch N, Coward RJ, Welsh GI, Foster RR, Satchell SC. Ramnath RD, et al. Among authors: gamez m. Kidney Int. 2020 May;97(5):951-965. doi: 10.1016/j.kint.2019.09.035. Epub 2019 Nov 2. Kidney Int. 2020. PMID: 32037077 Free PMC article.
Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx.
Crompton M, Ferguson JK, Ramnath RD, Onions KL, Ogier AS, Gamez M, Down CJ, Skinner L, Wong KH, Dixon LK, Sutak J, Harper SJ, Pontrelli P, Gesualdo L, Heerspink HL, Toto RD, Welsh GI, Foster RR, Satchell SC, Butler MJ. Crompton M, et al. Among authors: gamez m. JCI Insight. 2023 Mar 8;8(5):e154164. doi: 10.1172/jci.insight.154164. JCI Insight. 2023. PMID: 36749631 Free PMC article. Clinical Trial.
Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes.
Gamez M, Elhegni HE, Fawaz S, Ho KH, Campbell NW, Copland DA, Onions KL, Butler MJ, Wasson EJ, Crompton M, Ramnath RD, Qiu Y, Yamaguchi Y, Arkill KP, Bates DO, Turnbull JE, Zubkova OV, Welsh GI, Atan D, Satchell SC, Foster RR. Gamez M, et al. Cardiovasc Diabetol. 2024 Feb 1;23(1):50. doi: 10.1186/s12933-024-02133-1. Cardiovasc Diabetol. 2024. PMID: 38302978 Free PMC article.
221 results