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A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing.
Nitahara-Kasahara Y, Mizumoto S, Inoue YU, Saka S, Posadas-Herrera G, Nakamura-Takahashi A, Takahashi Y, Hashimoto A, Konishi K, Miyata S, Masuda C, Matsumoto E, Maruoka Y, Yoshizawa T, Tanase T, Inoue T, Yamada S, Nomura Y, Takeda S, Watanabe A, Kosho T, Okada T. Nitahara-Kasahara Y, et al. Among authors: watanabe a. Dis Model Mech. 2021 Dec 1;14(12):dmm048963. doi: 10.1242/dmm.048963. Epub 2021 Dec 23. Dis Model Mech. 2021. PMID: 34850861 Free PMC article.
Vascular type of Ehlers-Danlos syndrome.
Watanabe A, Shimada T. Watanabe A, et al. J Nippon Med Sch. 2008 Oct;75(5):254-61. doi: 10.1272/jnms.75.254. J Nippon Med Sch. 2008. PMID: 19023163 Free article. Review.
Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells.
Iijima O, Miyake K, Watanabe A, Miyake N, Igarashi T, Kanokoda C, Nakamura-Takahashi A, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millán JL, Okada T, Shimada T. Iijima O, et al. Among authors: watanabe a. Hum Gene Ther. 2015 Dec;26(12):801-12. doi: 10.1089/hum.2015.078. Epub 2015 Nov 19. Hum Gene Ther. 2015. PMID: 26467745 Free PMC article.
Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector.
Nakamura-Takahashi A, Miyake K, Watanabe A, Hirai Y, Iijima O, Miyake N, Adachi K, Nitahara-Kasahara Y, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millán JL, Shimada T, Okada T. Nakamura-Takahashi A, et al. Among authors: watanabe a. Mol Ther Methods Clin Dev. 2016 Feb 3;3:15059. doi: 10.1038/mtm.2015.59. eCollection 2016. Mol Ther Methods Clin Dev. 2016. PMID: 26904710 Free PMC article.
High-Level Expression of Alkaline Phosphatase by Adeno-Associated Virus Vector Ameliorates Pathological Bone Structure in a Hypophosphatasia Mouse Model.
Nakamura-Takahashi A, Tanase T, Matsunaga S, Shintani S, Abe S, Nitahara-Kasahara Y, Watanabe A, Hirai Y, Okada T, Yamaguchi A, Kasahara M. Nakamura-Takahashi A, et al. Among authors: watanabe a. Calcif Tissue Int. 2020 Jun;106(6):665-677. doi: 10.1007/s00223-020-00676-5. Epub 2020 Feb 19. Calcif Tissue Int. 2020. PMID: 32076747
Marked motor function improvement in a 32-year-old woman with childhood-onset hypophosphatasia by asfotase alfa therapy: Evaluation based on standardized testing batteries used in Duchenne muscular dystrophy clinical trials.
Nishizawa H, Sato Y, Ishikawa M, Arakawa Y, Iijima M, Akiyama T, Takano K, Watanabe A, Kosho T. Nishizawa H, et al. Among authors: watanabe a. Mol Genet Metab Rep. 2020 Sep 9;25:100643. doi: 10.1016/j.ymgmr.2020.100643. eCollection 2020 Dec. Mol Genet Metab Rep. 2020. PMID: 32983894 Free PMC article.
4,751 results