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Page 1
Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space.
Piticchio SG, Martínez-Cartró M, Scaffidi S, Rachman M, Rodriguez-Arevalo S, Sanchez-Arfelis A, Escolano C, Picaud S, Krojer T, Filippakopoulos P, von Delft F, Galdeano C, Barril X. Piticchio SG, et al. Among authors: scaffidi s. J Med Chem. 2021 Dec 23;64(24):17887-17900. doi: 10.1021/acs.jmedchem.1c01108. Epub 2021 Dec 13. J Med Chem. 2021. PMID: 34898210
Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.
Galdeano C, Gadd MS, Soares P, Scaffidi S, Van Molle I, Birced I, Hewitt S, Dias DM, Ciulli A. Galdeano C, et al. Among authors: scaffidi s. J Med Chem. 2014 Oct 23;57(20):8657-63. doi: 10.1021/jm5011258. Epub 2014 Oct 6. J Med Chem. 2014. PMID: 25166285 Free PMC article.
Spatial regulation of protein A in Staphylococcus aureus.
Zhang R, Shebes MA, Kho K, Scaffidi SJ, Meredith TC, Yu W. Zhang R, et al. Among authors: scaffidi sj. Mol Microbiol. 2021 Aug;116(2):589-605. doi: 10.1111/mmi.14734. Epub 2021 Jun 14. Mol Microbiol. 2021. PMID: 33949015 Free PMC article.