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Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy.
J Mol Cell Cardiol. 2022 Mar;164:148-155. doi: 10.1016/j.yjmcc.2021.12.003. Epub 2021 Dec 14.
J Mol Cell Cardiol. 2022.
PMID: 34919895
Free article.
Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism.
Tapio J, Halmetoja R, Dimova EY, Mäki JM, Laitala A, Walkinshaw G, Myllyharju J, Serpi R, Koivunen P.
Tapio J, et al. Among authors: halmetoja r.
J Biol Chem. 2022 Aug;298(8):102222. doi: 10.1016/j.jbc.2022.102222. Epub 2022 Jul 1.
J Biol Chem. 2022.
PMID: 35787374
Free PMC article.
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Hypoxia ameliorates maternal diet-induced insulin resistance during pregnancy while having a detrimental effect on the placenta.
Sissala N, Myllymäki E, Mohr F, Halmetoja R, Kuvaja P, Dimova EY, Koivunen P.
Sissala N, et al. Among authors: halmetoja r.
Physiol Rep. 2022 May;10(9):e15302. doi: 10.14814/phy2.15302.
Physiol Rep. 2022.
PMID: 35535947
Free PMC article.
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Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice.
Ala-Nisula T, Halmetoja R, Leinonen H, Kurkela M, Lipponen HR, Sakko S, Karpale M, Salo AM, Sissala N, Röning T, Raza GS, Mäkelä KA, Thevenot J, Herzig KH, Serpi R, Myllyharju J, Tanila H, Koivunen P, Dimova EY.
Ala-Nisula T, et al. Among authors: halmetoja r.
Pflugers Arch. 2024 Sep;476(9):1339-1351. doi: 10.1007/s00424-024-02920-5. Epub 2024 Feb 24.
Pflugers Arch. 2024.
PMID: 38396259
Free PMC article.
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