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Fragment-to-Lead Medicinal Chemistry Publications in 2020.
de Esch IJP, Erlanson DA, Jahnke W, Johnson CN, Walsh L. de Esch IJP, et al. Among authors: johnson cn. J Med Chem. 2022 Jan 13;65(1):84-99. doi: 10.1021/acs.jmedchem.1c01803. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928151 Free PMC article. Review.
Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.
Johnson CN, Berdini V, Beke L, Bonnet P, Brehmer D, Coyle JE, Day PJ, Frederickson M, Freyne EJ, Gilissen RA, Hamlett CC, Howard S, Meerpoel L, McMenamin R, Patel S, Rees DC, Sharff A, Sommen F, Wu T, Linders JT. Johnson CN, et al. ACS Med Chem Lett. 2014 May 23;6(1):25-30. doi: 10.1021/ml5001245. eCollection 2015 Jan 8. ACS Med Chem Lett. 2014. PMID: 25589925 Free PMC article.
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
Chessari G, Buck IM, Day JE, Day PJ, Iqbal A, Johnson CN, Lewis EJ, Martins V, Miller D, Reader M, Rees DC, Rich SJ, Tamanini E, Vitorino M, Ward GA, Williams PA, Williams G, Wilsher NE, Woolford AJ. Chessari G, et al. Among authors: johnson cn. J Med Chem. 2015 Aug 27;58(16):6574-88. doi: 10.1021/acs.jmedchem.5b00706. Epub 2015 Aug 7. J Med Chem. 2015. PMID: 26218264
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).
Tamanini E, Buck IM, Chessari G, Chiarparin E, Day JEH, Frederickson M, Griffiths-Jones CM, Hearn K, Heightman TD, Iqbal A, Johnson CN, Lewis EJ, Martins V, Peakman T, Reader M, Rich SJ, Ward GA, Williams PA, Wilsher NE. Tamanini E, et al. Among authors: johnson cn. J Med Chem. 2017 Jun 8;60(11):4611-4625. doi: 10.1021/acs.jmedchem.6b01877. Epub 2017 May 24. J Med Chem. 2017. PMID: 28492317
Fragment-to-Lead Medicinal Chemistry Publications in 2016.
Johnson CN, Erlanson DA, Jahnke W, Mortenson PN, Rees DC. Johnson CN, et al. J Med Chem. 2018 Mar 8;61(5):1774-1784. doi: 10.1021/acs.jmedchem.7b01298. Epub 2017 Oct 31. J Med Chem. 2018. PMID: 29087197 Review.
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).
Johnson CN, Ahn JS, Buck IM, Chiarparin E, Day JEH, Hopkins A, Howard S, Lewis EJ, Martins V, Millemaggi A, Munck JM, Page LW, Peakman T, Reader M, Rich SJ, Saxty G, Smyth T, Thompson NT, Ward GA, Williams PA, Wilsher NE, Chessari G. Johnson CN, et al. J Med Chem. 2018 Aug 23;61(16):7314-7329. doi: 10.1021/acs.jmedchem.8b00900. Epub 2018 Aug 9. J Med Chem. 2018. PMID: 30091600
Fragment-to-Lead Medicinal Chemistry Publications in 2017.
Mortenson PN, Erlanson DA, de Esch IJP, Jahnke W, Johnson CN. Mortenson PN, et al. Among authors: johnson cn. J Med Chem. 2019 Apr 25;62(8):3857-3872. doi: 10.1021/acs.jmedchem.8b01472. Epub 2018 Nov 21. J Med Chem. 2019. PMID: 30462504 Review.
Fragment-to-Lead Medicinal Chemistry Publications in 2018.
Erlanson DA, de Esch IJP, Jahnke W, Johnson CN, Mortenson PN. Erlanson DA, et al. Among authors: johnson cn. J Med Chem. 2020 May 14;63(9):4430-4444. doi: 10.1021/acs.jmedchem.9b01581. Epub 2020 Jan 22. J Med Chem. 2020. PMID: 31913033
Fragment-to-Lead Medicinal Chemistry Publications in 2019.
Jahnke W, Erlanson DA, de Esch IJP, Johnson CN, Mortenson PN, Ochi Y, Urushima T. Jahnke W, et al. Among authors: johnson cn. J Med Chem. 2020 Dec 24;63(24):15494-15507. doi: 10.1021/acs.jmedchem.0c01608. Epub 2020 Nov 23. J Med Chem. 2020. PMID: 33226222
322 results