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Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation.
Niyonzima N, Rahman J, Kunz N, West EE, Freiwald T, Desai JV, Merle NS, Gidon A, Sporsheim B, Lionakis MS, Evensen K, Lindberg B, Skagen K, Skjelland M, Singh P, Haug M, Ruseva MM, Kolev M, Bibby J, Marshall O, O'Brien B, Deeks N, Afzali B, Clark RJ, Woodruff TM, Pryor M, Yang ZH, Remaley AT, Mollnes TE, Hewitt SM, Yan B, Kazemian M, Kiss MG, Binder CJ, Halvorsen B, Espevik T, Kemper C. Niyonzima N, et al. Among authors: clark rj. Sci Immunol. 2021 Dec 24;6(66):eabf2489. doi: 10.1126/sciimmunol.abf2489. Epub 2021 Dec 24. Sci Immunol. 2021. PMID: 34932384 Free PMC article.
Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling.
Croker DE, Monk PN, Halai R, Kaeslin G, Schofield Z, Wu MC, Clark RJ, Blaskovich MA, Morikis D, Floudas CA, Cooper MA, Woodruff TM. Croker DE, et al. Among authors: clark rj. Immunol Cell Biol. 2016 Sep;94(8):787-95. doi: 10.1038/icb.2016.43. Epub 2016 Apr 25. Immunol Cell Biol. 2016. PMID: 27108698 Free article.
The "C3aR Antagonist" SB290157 is a Partial C5aR2 Agonist.
Li XX, Kumar V, Clark RJ, Lee JD, Woodruff TM. Li XX, et al. Among authors: clark rj. Front Pharmacol. 2021 Jan 21;11:591398. doi: 10.3389/fphar.2020.591398. eCollection 2020. Front Pharmacol. 2021. PMID: 33551801 Free PMC article.
319 results