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Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.
Welch N, Singh SS, Kumar A, Dhruba SR, Mishra S, Sekar J, Bellar A, Attaway AH, Chelluboyina A, Willard BB, Li L, Huo Z, Karnik SS, Esser K, Longworth MS, Shah YM, Davuluri G, Pal R, Dasarathy S. Welch N, et al. Among authors: davuluri g. J Biol Chem. 2021 Sep;297(3):101023. doi: 10.1016/j.jbc.2021.101023. Epub 2021 Jul 31. J Biol Chem. 2021. PMID: 34343564 Free PMC article.
Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations.
Kant S, Davuluri G, Alchirazi KA, Welch N, Heit C, Kumar A, Gangadhariah M, Kim A, McMullen MR, Willard B, Luse DS, Nagy LE, Vasiliou V, Marini AM, Weiner ID, Dasarathy S. Kant S, et al. Among authors: davuluri g. J Biol Chem. 2019 May 3;294(18):7231-7244. doi: 10.1074/jbc.RA118.005411. Epub 2019 Mar 14. J Biol Chem. 2019. PMID: 30872403 Free PMC article.
Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia.
Davuluri G, Giusto M, Chandel R, Welch N, Alsabbagh K, Kant S, Kumar A, Kim A, Gangadhariah M, Ghosh PK, Tran U, Krajcik DM, Vasu K, DiDonato AJ, DiDonato JA, Willard B, Monga SP, Wang Y, Fox PL, Stark GR, Wessely O, Esser KA, Dasarathy S. Davuluri G, et al. Mol Cell Biol. 2019 Jul 29;39(16):e00451-18. doi: 10.1128/MCB.00451-18. Print 2019 Aug 15. Mol Cell Biol. 2019. PMID: 31138664 Free PMC article.
Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy.
Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S. Kumar A, et al. Among authors: davuluri g. Free Radic Biol Med. 2019 Dec;145:284-299. doi: 10.1016/j.freeradbiomed.2019.09.031. Epub 2019 Sep 28. Free Radic Biol Med. 2019. PMID: 31574345 Free PMC article.
Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease.
Singh SS, Kumar A, Welch N, Sekar J, Mishra S, Bellar A, Gangadhariah M, Attaway A, Al Khafaji H, Wu X, Pathak V, Agrawal V, McMullen MR, Hornberger TA, Nagy LE, Davuluri G, Dasarathy S. Singh SS, et al. Among authors: davuluri g. Cell Physiol Biochem. 2021 Feb 6;55(1):91-116. doi: 10.33594/000000327. Cell Physiol Biochem. 2021. PMID: 33543862 Free PMC article.
Hyperammonemia results in reduced muscle function independent of muscle mass.
McDaniel J, Davuluri G, Hill EA, Moyer M, Runkana A, Prayson R, van Lunteren E, Dasarathy S. McDaniel J, et al. Among authors: davuluri g. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 1;310(3):G163-70. doi: 10.1152/ajpgi.00322.2015. Epub 2015 Dec 3. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 26635319 Free PMC article.
51 results