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Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease.
Singh SS, Kumar A, Welch N, Sekar J, Mishra S, Bellar A, Gangadhariah M, Attaway A, Al Khafaji H, Wu X, Pathak V, Agrawal V, McMullen MR, Hornberger TA, Nagy LE, Davuluri G, Dasarathy S. Singh SS, et al. Cell Physiol Biochem. 2021 Feb 6;55(1):91-116. doi: 10.33594/000000327. Cell Physiol Biochem. 2021. PMID: 33543862 Free PMC article.
Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.
Welch N, Singh SS, Kumar A, Dhruba SR, Mishra S, Sekar J, Bellar A, Attaway AH, Chelluboyina A, Willard BB, Li L, Huo Z, Karnik SS, Esser K, Longworth MS, Shah YM, Davuluri G, Pal R, Dasarathy S. Welch N, et al. Among authors: singh ss. J Biol Chem. 2021 Sep;297(3):101023. doi: 10.1016/j.jbc.2021.101023. Epub 2021 Jul 31. J Biol Chem. 2021. PMID: 34343564 Free PMC article.
Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis.
Attaway AH, Bellar A, Mishra S, Karthikeyan M, Sekar J, Welch N, Musich R, Singh SS, Kumar A, Menon A, King J, Langen R, Webster J, Scheraga RG, Rochon K, Mears J, Naga Prasad SV, Hatzoglou M, Chakraborty AA, Dasarathy S. Attaway AH, et al. Among authors: singh ss. J Physiol. 2023 Feb;601(3):567-606. doi: 10.1113/JP283700. Epub 2023 Jan 10. J Physiol. 2023. PMID: 36533558 Free PMC article.
Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin-mediated deacetylation.
Mishra S, Welch N, Karthikeyan M, Bellar A, Musich R, Singh SS, Zhang D, Sekar J, Attaway AH, Chelluboyina AK, Lorkowski SW, Roychowdhury S, Li L, Willard B, Smith JD, Hoppel CL, Vachharajani V, Kumar A, Dasarathy S. Mishra S, et al. Among authors: singh ss. Aging Cell. 2023 Jul;22(7):e13852. doi: 10.1111/acel.13852. Epub 2023 Apr 26. Aging Cell. 2023. PMID: 37101412 Free PMC article.
Ammonia transporter RhBG initiates downstream signaling and functional responses by activating NFκB.
Mishra S, Welch N, Singh SS, Singh KD, Bellar A, Kumar A, Deutz LN, Hanlon MD, Kant S, Dastidar S, Patel H, Agrawal V, Attaway AH, Musich R, Stark GR, Tedesco FS, Truskey GA, Weiner ID, Karnik SS, Dasarathy S. Mishra S, et al. Among authors: singh ss. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2314760121. doi: 10.1073/pnas.2314760121. Epub 2024 Jul 25. Proc Natl Acad Sci U S A. 2024. PMID: 39052834
Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation.
Jank L, Singh SS, Lee J, Dhukhwa A, Siavoshi F, Joshi D, Minney V, Gupta K, Ghimire S, Deme P, Schoeps VA, Soman K, Ladakis D, Smith M, Borkowski K, Newman J, Baranzini SE, Waubant EL, Fitzgerald KC, Mangalam A, Haughey N, Kornberg M, Chamling X, Calabresi PA, Bhargava P. Jank L, et al. Among authors: singh ss. bioRxiv [Preprint]. 2024 Oct 28:2024.10.27.620437. doi: 10.1101/2024.10.27.620437. bioRxiv. 2024. PMID: 39554063 Free PMC article. Preprint.
642 results