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Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors.
Diamond JR, Pitts TM, Ungermannova D, Nasveschuk CG, Zhang G, Phillips AJ, Bagby SM, Pafford J, Yacob BW, Newton TP, Tentler JJ, Gittleman B, Hartman SJ, DeMattei JA, Winkler JD, Wendt MK, Schiemann WP, Eckhardt SG, Liu X, Piscopio AD. Diamond JR, et al. Among authors: phillips aj. Mol Cancer Ther. 2022 Mar 1;21(3):397-406. doi: 10.1158/1535-7163.MCT-21-0455. Mol Cancer Ther. 2022. PMID: 34965958 Free PMC article.
Identification and mechanistic studies of a novel ubiquitin E1 inhibitor.
Ungermannova D, Parker SJ, Nasveschuk CG, Chapnick DA, Phillips AJ, Kuchta RD, Liu X. Ungermannova D, et al. Among authors: phillips aj. J Biomol Screen. 2012 Apr;17(4):421-34. doi: 10.1177/1087057111433843. Epub 2012 Jan 24. J Biomol Screen. 2012. PMID: 22274912 Free PMC article.
Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models.
Sun D, Nikonova AS, Zhang P, Deneka AY, Fitzgerald ME, Michael RE, Lee L, Lilly AC, Fisher SL, Phillips AJ, Nasveschuk CG, Proia DA, Tu Z, Golemis EA. Sun D, et al. Among authors: phillips aj. Mol Cancer Ther. 2021 Aug;20(8):1367-1377. doi: 10.1158/1535-7163.MCT-20-0831. Epub 2021 May 27. Mol Cancer Ther. 2021. PMID: 34045230 Free PMC article.
Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen-Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design.
Eron SJ, Huang H, Agafonov RV, Fitzgerald ME, Patel J, Michael RE, Lee TD, Hart AA, Shaulsky J, Nasveschuk CG, Phillips AJ, Fisher SL, Good A. Eron SJ, et al. Among authors: phillips aj. ACS Chem Biol. 2021 Nov 19;16(11):2228-2243. doi: 10.1021/acschembio.1c00376. Epub 2021 Sep 28. ACS Chem Biol. 2021. PMID: 34582690 Free article.
A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination.
Vieux EF, Agafonov RV, Emerson L, Isasa M, Deibler RW, Simard JR, Cocozziello D, Ladd B, Lee L, Li H, Archer S, Fitzgerald M, Michael R, Nasveschuk CG, Park ES, Kern G, Proia DA, Phillips AJ, Fisher SL. Vieux EF, et al. Among authors: phillips aj. SLAS Discov. 2021 Apr;26(4):547-559. doi: 10.1177/24725552211000673. SLAS Discov. 2021. PMID: 33780296 Free article.
The halichondrins and E7389.
Jackson KL, Henderson JA, Phillips AJ. Jackson KL, et al. Among authors: phillips aj. Chem Rev. 2009 Jul;109(7):3044-79. doi: 10.1021/cr900016w. Chem Rev. 2009. PMID: 19534494 Review. No abstract available.
378 results