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The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.
Cogo S, Ho FY, Tosoni E, Tomkins JE, Tessari I, Iannotta L, Montine TJ, Manzoni C, Lewis PA, Bubacco L, Chartier Harlin MC, Taymans JM, Kortholt A, Nichols J, Cendron L, Civiero L, Greggio E. Cogo S, et al. Among authors: lewis pa. Brain Res. 2022 Mar 1;1778:147781. doi: 10.1016/j.brainres.2022.147781. Epub 2022 Jan 10. Brain Res. 2022. PMID: 35016853
The R1441C mutation of LRRK2 disrupts GTP hydrolysis.
Lewis PA, Greggio E, Beilina A, Jain S, Baker A, Cookson MR. Lewis PA, et al. Biochem Biophys Res Commun. 2007 Jun 8;357(3):668-71. doi: 10.1016/j.bbrc.2007.04.006. Epub 2007 Apr 10. Biochem Biophys Res Commun. 2007. PMID: 17442267 Free PMC article.
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
Li Y, Dunn L, Greggio E, Krumm B, Jackson GS, Cookson MR, Lewis PA, Deng J. Li Y, et al. Among authors: lewis pa. Biochim Biophys Acta. 2009 Dec;1792(12):1194-7. doi: 10.1016/j.bbadis.2009.09.010. Epub 2009 Sep 23. Biochim Biophys Acta. 2009. PMID: 19781641 Free PMC article.
Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
Devine MJ, Kaganovich A, Ryten M, Mamais A, Trabzuni D, Manzoni C, McGoldrick P, Chan D, Dillman A, Zerle J, Horan S, Taanman JW, Hardy J, Marti-Masso JF, Healy D, Schapira AH, Wolozin B, Bandopadhyay R, Cookson MR, van der Brug MP, Lewis PA. Devine MJ, et al. Among authors: lewis pa. PLoS One. 2011;6(7):e22489. doi: 10.1371/journal.pone.0022489. Epub 2011 Jul 22. PLoS One. 2011. PMID: 21799870 Free PMC article.
Gene expression in the Parkinson's disease brain.
Lewis PA, Cookson MR. Lewis PA, et al. Brain Res Bull. 2012 Jul 1;88(4):302-12. doi: 10.1016/j.brainresbull.2011.11.016. Epub 2011 Dec 3. Brain Res Bull. 2012. PMID: 22173063 Free PMC article. Review.
374 results