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Carmaphycin B-Based Proteasome Inhibitors to Treat Human African Trypanosomiasis: Structure-Activity Relationship and In Vivo Efficacy.
Liu LJ, Francisco KR, Sun YU, Serafim MSM, Amarasinghe DK, Teixeira TR, Lucero B, Kronenberger T, Elsayed W, Elwakeel H, Al-Hindy M, Almaliti J, Gerwick WH, O'Donoghue AJ, Caffrey CR. Liu LJ, et al. Among authors: o donoghue aj. ACS Infect Dis. 2024 Nov 26. doi: 10.1021/acsinfecdis.4c00441. Online ahead of print. ACS Infect Dis. 2024. PMID: 39589805
Evaluating Antimalarial Proteasome Inhibitors for Efficacy in Babesia Blood Stage Cultures.
Robbertse L, Fajtová P, Šnebergerová P, Jalovecká M, Levytska V, Barbosa da Silva E, Sharma V, Pachl P, Almaliti J, Al-Hindy M, Gerwick WH, Bouřa E, O'Donoghue AJ, Sojka D. Robbertse L, et al. Among authors: o donoghue aj. ACS Omega. 2024 Oct 28;9(45):44989-44999. doi: 10.1021/acsomega.4c04564. eCollection 2024 Nov 12. ACS Omega. 2024. PMID: 39554424 Free PMC article.
Development of an Antiviral Medicinal Plant and Natural Product Database (avMpNp Database) from Biodiversity.
Quadros de Azevedo D, Vinícius Viera Nóia J, Ribeiro YCM, Alves Dos Reis R, Ribeiro PHO, Almeida Moura G, Mendes P, Barbosa de Souza AB, Carpini Mermejo S, Serafim MSM, Fernandes THM, O'Donoghue AJ, Campos ACFA, Campos SVA, Gonçalves Maltarollo V, Oliveira Castilho R. Quadros de Azevedo D, et al. Among authors: o donoghue aj. Chem Biodivers. 2024 Nov 15:e202400285. doi: 10.1002/cbdv.202400285. Online ahead of print. Chem Biodivers. 2024. PMID: 39546588
Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (S, Se) and Their Azole Derivatives against Chagas Disease.
Rubio-Hernández M, Alcolea V, Barbosa da Silva E, Giardini MA, M Fernandes TH, Martínez-Sáez N, O'Donoghue AJ, Siqueira-Neto JL, Pérez-Silanes S. Rubio-Hernández M, et al. Among authors: o donoghue aj. J Med Chem. 2024 Nov 14;67(21):19038-19056. doi: 10.1021/acs.jmedchem.4c01535. Epub 2024 Nov 1. J Med Chem. 2024. PMID: 39485736
An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4.
Bhaduri S, Braza MKE, Stanchev S, Tauber M, Al-Bawab R, Liu LJ, Trujillo DF, Solorio-Kirpichyan K, Srivastava A, Sanlley-Hernandez J, O'Donoghue AJ, Lemberg MK, Amario R, Strisovsky K, Neal SE. Bhaduri S, et al. Among authors: o donoghue aj. bioRxiv [Preprint]. 2024 Oct 17:2024.10.13.618094. doi: 10.1101/2024.10.13.618094. bioRxiv. 2024. PMID: 39415989 Free PMC article. Preprint.
126 results