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Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance.
Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators§; LITMUS Consortium Investigators. Johnson K, et al. Among authors: leary pj. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. eCollection 2022 Feb. JHEP Rep. 2021. PMID: 35072021 Free PMC article.
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.
Hunter JE, Campbell AE, Hannaway NL, Kerridge S, Luli S, Butterworth JA, Sellier H, Mukherjee R, Dhillon N, Sudhindar PD, Shukla R, Brownridge PJ, Bell HL, Coxhead J, Taylor L, Leary P, Hasoon MSR, Collins I, Garrett MD, Eyers CE, Perkins ND. Hunter JE, et al. Among authors: leary p. Biochem J. 2022 Oct 14;479(19):2063-2086. doi: 10.1042/BCJ20220102. Biochem J. 2022. PMID: 36240066 Free PMC article.
Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance.
Hunter JE, Campbell AE, Butterworth JA, Sellier H, Hannaway NL, Luli S, Floudas A, Kenneth NS, Moore AJ, Brownridge PJ, Thomas HD, Coxhead J, Taylor L, Leary P, Hasoon MSR, Knight AM, Garrett MD, Collins I, Eyers CE, Perkins ND. Hunter JE, et al. Among authors: leary p. Biochem J. 2022 Oct 14;479(19):2087-2113. doi: 10.1042/BCJ20220089. Biochem J. 2022. PMID: 36240065 Free PMC article. No abstract available.
Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension.
Philip N, Yun X, Pi H, Murray S, Hill Z, Fonticella J, Perez P, Zhang C, Pathmasiri W, Sumner S, Servinsky L, Jiang H, Huetsch JC, Oldham WM, Visovatti S, Leary PJ, Gharib SA, Brittain E, Simpson CE, Le A, Shimoda LA, Suresh K. Philip N, et al. Among authors: leary pj. Am J Physiol Lung Cell Mol Physiol. 2024 Mar 1;326(3):L252-L265. doi: 10.1152/ajplung.00199.2023. Epub 2024 Jan 16. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 38226418
Premorbid weight in pulmonary arterial hypertension.
Oppegard LJ, Barros LM, Pi H, Kornfield J, Hough CL, Rayner SG, Robinson JC, Leary PJ. Oppegard LJ, et al. Among authors: leary pj. Pulm Circ. 2023 Nov 21;13(4):e12308. doi: 10.1002/pul2.12308. eCollection 2023 Oct. Pulm Circ. 2023. PMID: 38027456 Free PMC article.
84 results