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Molecular Engineering of Efficacious Mono-Valent Ultra-Long Acting Two-Chain Insulin-Fc Conjugates.
Tagmose TM, Pedersen KM, Pridal L, Stidsen CE, Pedersen MØ, Lin Z, Zhang Y, Wan Z, Ferreras M, Naver H, Nielsen PK, Cao Z, Wang Y, Lykke L, Christensen JL, Jensen VS, Manfè V, Pedersen TÅ, Johansson E, Madsen P, Kodra JT, Münzel M, De Maria L, Nishimura E, Kjeldsen TB. Tagmose TM, et al. Among authors: cao z. J Med Chem. 2022 Feb 10;65(3):2633-2645. doi: 10.1021/acs.jmedchem.1c02039. Epub 2022 Feb 1. J Med Chem. 2022. PMID: 35104142
A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs.
Condado-Morales I, Dingfelder F, Waibel I, Turnbull OM, Patel B, Cao Z, Rose Bjelke J, Nedergaard Grell S, Bennet A, Hummer AM, Raybould MIJ, Deane CM, Egebjerg T, Lorenzen N, Arosio P. Condado-Morales I, et al. Among authors: cao z. MAbs. 2024 Jan-Dec;16(1):2403156. doi: 10.1080/19420862.2024.2403156. Epub 2024 Oct 4. MAbs. 2024. PMID: 39364796 Free PMC article.
9,649 results