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Page 1
Molecular Engineering of Efficacious Mono-Valent Ultra-Long Acting Two-Chain Insulin-Fc Conjugates.
Tagmose TM, Pedersen KM, Pridal L, Stidsen CE, Pedersen MØ, Lin Z, Zhang Y, Wan Z, Ferreras M, Naver H, Nielsen PK, Cao Z, Wang Y, Lykke L, Christensen JL, Jensen VS, Manfè V, Pedersen TÅ, Johansson E, Madsen P, Kodra JT, Münzel M, De Maria L, Nishimura E, Kjeldsen TB. Tagmose TM, et al. Among authors: kodra jt. J Med Chem. 2022 Feb 10;65(3):2633-2645. doi: 10.1021/acs.jmedchem.1c02039. Epub 2022 Feb 1. J Med Chem. 2022. PMID: 35104142
Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320.
Kjeldsen TB, Hubálek F, Tagmose TM, Pridal L, Refsgaard HHF, Porsgaard T, Gram-Nielsen S, Hovgaard L, Valore H, Münzel M, Hjørringgaard CU, Jeppesen CB, Manfè V, Hoeg-Jensen T, Ludvigsen S, Nielsen PK, Lautrup-Larsen I, Stidsen CE, Wulff EM, Garibay PW, Kodra JT, Nishimura E, Madsen P. Kjeldsen TB, et al. Among authors: kodra jt. J Med Chem. 2021 Jan 14;64(1):616-628. doi: 10.1021/acs.jmedchem.0c01576. Epub 2020 Dec 28. J Med Chem. 2021. PMID: 33356257
An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor.
Bhushan B, Granata D, Kaas CS, Kasimova MA, Ren Q, Cramer CN, White MD, Hansen AMK, Fledelius C, Invernizzi G, Deibler K, Coleman OD, Zhao X, Qu X, Liu H, Zurmühl SS, Kodra JT, Kawamura A, Münzel M. Bhushan B, et al. Among authors: kodra jt. Chem Sci. 2022 Feb 24;13(11):3256-3262. doi: 10.1039/d1sc06844j. eCollection 2022 Mar 16. Chem Sci. 2022. PMID: 35414877 Free PMC article.
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.
Teng M, Johnson MD, Thomas C, Kiel D, Lakis JN, Kercher T, Aytes S, Kostrowicki J, Bhumralkar D, Truesdale L, May J, Sidelman U, Kodra JT, Jørgensen AS, Olesen PH, de Jong JC, Madsen P, Behrens C, Pettersson I, Knudsen LB, Holst JJ, Lau J. Teng M, et al. Among authors: kodra jt. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5472-8. doi: 10.1016/j.bmcl.2007.06.086. Epub 2007 Jul 4. Bioorg Med Chem Lett. 2007. PMID: 17827014
Small-molecule agonists for the glucagon-like peptide 1 receptor.
Knudsen LB, Kiel D, Teng M, Behrens C, Bhumralkar D, Kodra JT, Holst JJ, Jeppesen CB, Johnson MD, de Jong JC, Jorgensen AS, Kercher T, Kostrowicki J, Madsen P, Olesen PH, Petersen JS, Poulsen F, Sidelmann UG, Sturis J, Truesdale L, May J, Lau J. Knudsen LB, et al. Among authors: kodra jt. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):937-42. doi: 10.1073/pnas.0605701104. Epub 2007 Jan 9. Proc Natl Acad Sci U S A. 2007. PMID: 17213325 Free PMC article.
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