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Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis.
Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z, Kupper TS, Lieberman J, Liu X. Deng W, et al. Among authors: liu x. Nature. 2022 Feb;602(7897):496-502. doi: 10.1038/s41586-021-04384-4. Epub 2022 Feb 2. Nature. 2022. PMID: 35110732 Free PMC article.
How ICE lights the pyroptosis fire.
Liu X, Lieberman J. Liu X, et al. Cell Death Differ. 2017 Feb;24(2):197-199. doi: 10.1038/cdd.2016.157. Epub 2017 Jan 6. Cell Death Differ. 2017. PMID: 28060375 Free PMC article. No abstract available.
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H. Hu JJ, et al. Among authors: liu x. Nat Immunol. 2020 Jul;21(7):736-745. doi: 10.1038/s41590-020-0669-6. Epub 2020 May 4. Nat Immunol. 2020. PMID: 32367036 Free PMC article.
Channelling inflammation: gasdermins in physiology and disease.
Liu X, Xia S, Zhang Z, Wu H, Lieberman J. Liu X, et al. Nat Rev Drug Discov. 2021 May;20(5):384-405. doi: 10.1038/s41573-021-00154-z. Epub 2021 Mar 10. Nat Rev Drug Discov. 2021. PMID: 33692549 Free PMC article. Review.
STING inhibitors target the cyclic dinucleotide binding pocket.
Hong Z, Mei J, Li C, Bai G, Maimaiti M, Hu H, Yu W, Sun L, Zhang L, Cheng D, Liao Y, Li S, You Y, Sun H, Huang J, Liu X, Lieberman J, Wang C. Hong Z, et al. Among authors: liu x. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118. doi: 10.1073/pnas.2105465118. Proc Natl Acad Sci U S A. 2021. PMID: 34099558 Free PMC article.
TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization.
Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H, Chen X, Li J. Gao W, et al. Among authors: liu k, liu x. Cell Death Differ. 2022 Feb;29(2):439-450. doi: 10.1038/s41418-021-00867-z. Epub 2021 Sep 11. Cell Death Differ. 2022. PMID: 34511601 Free PMC article.
135,089 results
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