Lake AD - Search Results

1

Neurotoxicity of an Hepatitis B Virus (HBV) Transcript Inhibitor in 13-Week Rat and Monkey Studies.

Lake AD, Holsapple K, McDonnell T, Arezzo JC, Ramirez R, Gamelin L, Yu M, Glatt D, Dick R, Xie X, Choy R, Cheng G, Tay CH, Chester A, Kato D, Burns-Naas LA. Lake AD, et al. Toxicol Sci. 2022 Mar 28;186(2):298-308. doi: 10.1093/toxsci/kfac009. Toxicol Sci. 2022. PMID: 35134235

2

Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action.

Lake AD, Wood CE, Bhat VS, Chorley BN, Carswell GK, Sey YM, Kenyon EM, Padnos B, Moore TM, Tennant AH, Schmid JE, George BJ, Ross DG, Hughes MF, Corton JC, Simmons JE, McQueen CA, Hester SD. Lake AD, et al. Toxicol Sci. 2016 Feb;149(2):312-25. doi: 10.1093/toxsci/kfv236. Epub 2015 Oct 31. Toxicol Sci. 2016. PMID: 26519955

3

Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis.

Hardwick RN, Clarke JD, Lake AD, Canet MJ, Anumol T, Street SM, Merrell MD, Goedken MJ, Snyder SA, Cherrington NJ. Hardwick RN, et al. Among authors: lake ad. Toxicol Sci. 2014 Nov;142(1):45-55. doi: 10.1093/toxsci/kfu156. Epub 2014 Jul 31. Toxicol Sci. 2014. PMID: 25080921 Free PMC article.

4

Latent carcinogenicity of early-life exposure to dichloroacetic acid in mice.

Wood CE, Hester SD, Chorley BN, Carswell G, George MH, Ward W, Vallanat B, Ren H, Fisher A, Lake AD, Okerberg CV, Gaillard ET, Moore TM, Deangelo AB. Wood CE, et al. Among authors: lake ad. Carcinogenesis. 2015 Jul;36(7):782-91. doi: 10.1093/carcin/bgv057. Epub 2015 Apr 25. Carcinogenesis. 2015. PMID: 25913432

5

Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease.

Hardwick RN, Fisher CD, Canet MJ, Lake AD, Cherrington NJ. Hardwick RN, et al. Among authors: lake ad. Drug Metab Dispos. 2010 Dec;38(12):2293-301. doi: 10.1124/dmd.110.035006. Epub 2010 Aug 30. Drug Metab Dispos. 2010. PMID: 20805291 Free PMC article.

6

Altered arsenic disposition in experimental nonalcoholic fatty liver disease.

Canet MJ, Hardwick RN, Lake AD, Kopplin MJ, Scheffer GL, Klimecki WT, Gandolfi AJ, Cherrington NJ. Canet MJ, et al. Among authors: lake ad. Drug Metab Dispos. 2012 Sep;40(9):1817-24. doi: 10.1124/dmd.112.046177. Epub 2012 Jun 14. Drug Metab Dispos. 2012. PMID: 22699396 Free PMC article.

7

The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease.

Lake AD, Novak P, Hardwick RN, Flores-Keown B, Zhao F, Klimecki WT, Cherrington NJ. Lake AD, et al. Toxicol Sci. 2014 Jan;137(1):26-35. doi: 10.1093/toxsci/kft230. Epub 2013 Oct 4. Toxicol Sci. 2014. PMID: 24097666 Free PMC article.

8

Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis.

Clarke JD, Sharapova T, Lake AD, Blomme E, Maher J, Cherrington NJ. Clarke JD, et al. Among authors: lake ad. J Appl Toxicol. 2014 Jun;34(6):726-32. doi: 10.1002/jat.2960. Epub 2013 Nov 12. J Appl Toxicol. 2014. PMID: 24217942 Free PMC article.

9

Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models.

Canet MJ, Hardwick RN, Lake AD, Dzierlenga AL, Clarke JD, Cherrington NJ. Canet MJ, et al. Among authors: lake ad. Drug Metab Dispos. 2014 Apr;42(4):586-95. doi: 10.1124/dmd.113.055996. Epub 2014 Jan 2. Drug Metab Dispos. 2014. PMID: 24384915 Free PMC article.

10

Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression.

Clarke JD, Hardwick RN, Lake AD, Canet MJ, Cherrington NJ. Clarke JD, et al. Among authors: lake ad. J Pharmacol Exp Ther. 2014 Mar;348(3):452-8. doi: 10.1124/jpet.113.211284. Epub 2014 Jan 8. J Pharmacol Exp Ther. 2014. PMID: 24403518 Free PMC article.

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