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102 results

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Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics.
Quinn TM, Gaughan EE, Bruce A, Antonelli J, O'Connor R, Li F, McNamara S, Koch O, MacKintosh C, Dockrell D, Walsh T, Blyth KG, Church C, Schwarze J, Boz C, Valanciute A, Burgess M, Emanuel P, Mills B, Rinaldi G, Hardisty G, Mills R, Findlay EG, Jabbal S, Duncan A, Plant S, Marshall ADL, Young I, Russell K, Scholefield E, Nimmo AF, Nazarov IB, Churchill GC, McCullagh JSO, Ebrahimi KH, Ferrett C, Templeton K, Rannard S, Owen A, Moore A, Finlayson K, Shankar-Hari M, Norrie J, Parker RA, Akram AR, Anthony DC, Dear JW, Hirani N, Dhaliwal K. Quinn TM, et al. Among authors: churchill gc. EBioMedicine. 2022 Feb;76:103856. doi: 10.1016/j.ebiom.2022.103856. Epub 2022 Feb 11. EBioMedicine. 2022. PMID: 35152152 Free PMC article. Clinical Trial.
Synthesis of NAADP-AM as a membrane-permeant NAADP analog.
Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC. Galione A, et al. Among authors: churchill gc. Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot076927. doi: 10.1101/pdb.prot076927. Cold Spring Harb Protoc. 2014. PMID: 25275101
Ebselen has lithium-like effects on central 5-HT2A receptor function.
Antoniadou I, Kouskou M, Arsiwala T, Singh N, Vasudevan SR, Fowler T, Cadirci E, Churchill GC, Sharp T. Antoniadou I, et al. Among authors: churchill gc. Br J Pharmacol. 2018 Jul;175(13):2599-2610. doi: 10.1111/bph.14179. Epub 2018 May 22. Br J Pharmacol. 2018. PMID: 29488218 Free PMC article.
Synthesis of [³²P]NAADP for the radioreceptor binding assay.
Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC. Galione A, et al. Among authors: churchill gc. Cold Spring Harb Protoc. 2014 Sep 2;2014(9):993-5. doi: 10.1101/pdb.prot076919. Cold Spring Harb Protoc. 2014. PMID: 25183813
Sperm express a Ca2+-regulated NAADP synthase.
Vasudevan SR, Galione A, Churchill GC. Vasudevan SR, et al. Among authors: churchill gc. Biochem J. 2008 Apr 1;411(1):63-70. doi: 10.1042/BJ20071616. Biochem J. 2008. PMID: 18215126 Free PMC article.
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.
Ruas M, Rietdorf K, Arredouani A, Davis LC, Lloyd-Evans E, Koegel H, Funnell TM, Morgan AJ, Ward JA, Watanabe K, Cheng X, Churchill GC, Zhu MX, Platt FM, Wessel GM, Parrington J, Galione A. Ruas M, et al. Among authors: churchill gc. Curr Biol. 2010 Apr 27;20(8):703-9. doi: 10.1016/j.cub.2010.02.049. Epub 2010 Mar 25. Curr Biol. 2010. PMID: 20346675 Free PMC article.
102 results