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139 results

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Page 1
Clinical trials in pediatric ALS: a TRICALS feasibility study.
Kliest T, Van Eijk RPA, Al-Chalabi A, Albanese A, Andersen PM, Amador MDM, BrÅthen G, Brunaud-Danel V, Brylev L, Camu W, De Carvalho M, Cereda C, Cetin H, Chaverri D, Chiò A, Corcia P, Couratier P, De Marchi F, Desnuelle C, Van Es MA, Esteban J, Filosto M, GarcÍa Redondo A, Grosskreutz J, Hanemann CO, HolmØy T, HØyer H, Ingre C, Koritnik B, Kuzma-Kozakiewicz M, Lambert T, Leigh PN, Lunetta C, Mandrioli J, Mcdermott CJ, Meyer T, Mora JS, Petri S, Povedano M, Reviers E, Riva N, Roes KCB, Rubio MÁ, Salachas F, Sarafov S, SorarÙ G, Stevic Z, Svenstrup K, MØller AT, Turner MR, Van Damme P, Van Leeuwen LAG, Varona L, VÁzquez Costa JF, Weber M, Hardiman O, Van Den Berg LH. Kliest T, et al. Among authors: roes kcb. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Nov;23(7-8):481-488. doi: 10.1080/21678421.2021.2024856. Epub 2022 Feb 16. Amyotroph Lateral Scler Frontotemporal Degener. 2022. PMID: 35172656 Free PMC article.
Critical design considerations for time-to-event endpoints in amyotrophic lateral sclerosis clinical trials.
van Eijk RPA, Nikolakopoulos S, Roes KCB, Middelkoop BM, Ferguson TA, Shaw PJ, Leigh PN, Al-Chalabi A, Eijkemans MJC, van den Berg LH. van Eijk RPA, et al. Among authors: roes kcb. J Neurol Neurosurg Psychiatry. 2019 Dec;90(12):1331-1337. doi: 10.1136/jnnp-2019-320998. Epub 2019 Jul 10. J Neurol Neurosurg Psychiatry. 2019. PMID: 31292200 Free PMC article.
TRICALS: creating a highway toward a cure.
van Eijk RPA, Kliest T, McDermott CJ, Roes KCB, Van Damme P, Chio A, Weber M, Ingre C, Corcia P, Povedano M, Reviers E, van Es MA, Al-Chalabi A, Hardiman O, van den Berg LH. van Eijk RPA, et al. Among authors: roes kcb. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Nov;21(7-8):496-501. doi: 10.1080/21678421.2020.1788092. Epub 2020 Jul 9. Amyotroph Lateral Scler Frontotemporal Degener. 2020. PMID: 32643415 Free article.
An old friend who has overstayed their welcome: the ALSFRS-R total score as primary endpoint for ALS clinical trials.
van Eijk RPA, de Jongh AD, Nikolakopoulos S, McDermott CJ, Eijkemans MJC, Roes KCB, van den Berg LH. van Eijk RPA, et al. Among authors: roes kcb. Amyotroph Lateral Scler Frontotemporal Degener. 2021 May;22(3-4):300-307. doi: 10.1080/21678421.2021.1879865. Epub 2021 Feb 2. Amyotroph Lateral Scler Frontotemporal Degener. 2021. PMID: 33527843 Free article.
Innovating Clinical Trials for Amyotrophic Lateral Sclerosis: Challenging the Established Order.
van Eijk RPA, Nikolakopoulos S, Roes KCB, Kendall L, Han SS, Lavrov A, Epstein N, Kliest T, de Jongh AD, Westeneng HJ, Al-Chalabi A, Van Damme P, Hardiman O, Shaw PJ, McDermott CJ, Eijkemans MJC, van den Berg LH. van Eijk RPA, et al. Among authors: roes kcb. Neurology. 2021 Sep 14;97(11):528-536. doi: 10.1212/WNL.0000000000012545. Epub 2021 Jul 27. Neurology. 2021. PMID: 34315786 Free PMC article.
A Road Map for Remote Digital Health Technology for Motor Neuron Disease.
van Eijk RPA, Beelen A, Kruitwagen ET, Murray D, Radakovic R, Hobson E, Knox L, Helleman J, Burke T, Rubio Pérez MÁ, Reviers E, Genge A, Steyn FJ, Ngo S, Eaglesham J, Roes KCB, van den Berg LH, Hardiman O, McDermott CJ. van Eijk RPA, et al. Among authors: roes kcb. J Med Internet Res. 2021 Sep 22;23(9):e28766. doi: 10.2196/28766. J Med Internet Res. 2021. PMID: 34550089 Free PMC article.
Lithium carbonate in amyotrophic lateral sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A: protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial.
Willemse SW, Roes KCB, Van Damme P, Hardiman O, Ingre C, Povedano M, Wray NR, Gijzen M, de Pagter MS, Demaegd KC, Janse AFC, Vink RG, Sleutjes BTHM, Chiò A, Corcia P, Reviers E, Al-Chalabi A, Kiernan MC, van den Berg LH, van Es MA, van Eijk RPA. Willemse SW, et al. Among authors: roes kcb. Trials. 2022 Dec 5;23(1):978. doi: 10.1186/s13063-022-06906-5. Trials. 2022. PMID: 36471413 Free PMC article.
Randomized double-blind placebo-controlled crossover trial with pyridostigmine in spinal muscular atrophy types 2-4.
Stam M, Wijngaarde CA, Bartels B, Asselman FL, Otto LAM, Habets LE, van Eijk RPA, Middelkoop BM, Goedee HS, de Groot JF, Roes KCB, Schoenmakers MAGC, Nieuwenhuis EES, Cuppen I, van den Berg LH, Wadman RI, van der Pol WL. Stam M, et al. Among authors: roes kcb. Brain Commun. 2022 Dec 9;5(1):fcac324. doi: 10.1093/braincomms/fcac324. eCollection 2023. Brain Commun. 2022. PMID: 36632180 Free PMC article.
139 results