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An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis.
Hards K, Cheung CY, Waller N, Adolph C, Keighley L, Tee ZS, Harold LK, Menorca A, Bujaroski RS, Buckley BJ, Tyndall JDA, McNeil MB, Rhee KY, Opel-Reading HK, Krause K, Preiss L, Langer JD, Meier T, Hasenoehrl EJ, Berney M, Kelso MJ, Cook GM. Hards K, et al. Among authors: keighley l. Commun Biol. 2022 Feb 24;5(1):166. doi: 10.1038/s42003-022-03110-8. Commun Biol. 2022. PMID: 35210534 Free PMC article.
Synthesis and Biological Evaluation of Aurachin D Analogues as Inhibitors of Mycobacterium tuberculosis Cytochrome bd Oxidase.
Lawer A, Tyler C, Hards K, Keighley LM, Cheung CY, Kierek F, Su S, Matikonda SS, McInnes T, Tyndall JDA, Krause KL, Cook GM, Gamble AB. Lawer A, et al. Among authors: keighley lm. ACS Med Chem Lett. 2022 Sep 26;13(10):1663-1669. doi: 10.1021/acsmedchemlett.2c00401. eCollection 2022 Oct 13. ACS Med Chem Lett. 2022. PMID: 36262396 Free PMC article.
Identification of Chemical Scaffolds That Inhibit the Mycobacterium tuberculosis Respiratory Complex Succinate Dehydrogenase.
Adolph C, Hards K, Williams ZC, Cheung CY, Keighley LM, Jowsey WJ, Kyte M, Inaoka DK, Kita K, Mackenzie JS, Steyn AJC, Li Z, Yan M, Tian GB, Zhang T, Ding X, Furkert DP, Brimble MA, Hickey AJR, McNeil MB, Cook GM. Adolph C, et al. Among authors: keighley lm. ACS Infect Dis. 2024 Oct 11;10(10):3496-3515. doi: 10.1021/acsinfecdis.3c00655. Epub 2024 Sep 13. ACS Infect Dis. 2024. PMID: 39268963
Real World Experience of Change in Psycho-Existential Symptoms in Palliative Care.
Kissane DW, Bobevski I, Appleton J, Michael N, King T, Moss G, Eng D, White A, Carboon D, Eade R, Keighley L. Kissane DW, et al. Among authors: keighley l. J Pain Symptom Manage. 2023 Sep;66(3):212-220.e2. doi: 10.1016/j.jpainsymman.2023.05.015. Epub 2023 Jun 7. J Pain Symptom Manage. 2023. PMID: 37290732 Free article.
Relevance of clotting screen requests.
Morris R, Thorell S, Keighley L, Belli H, Thachil J. Morris R, et al. Among authors: keighley l. Eur J Intern Med. 2014 Nov;25(9):e111-2. doi: 10.1016/j.ejim.2014.10.002. Epub 2014 Oct 11. Eur J Intern Med. 2014. PMID: 25306176 No abstract available.
17 results