Chen LN - Search Results

1

Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.

Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW. Zhao F, et al. Among authors: chen ln, chen y. Nat Commun. 2022 Feb 25;13(1):1057. doi: 10.1038/s41467-022-28683-0. Nat Commun. 2022. PMID: 35217653 Free PMC article.

2

Cryo-EM structures of inactive and active GABA_B receptor.

Mao C, Shen C, Li C, Shen DD, Xu C, Zhang S, Zhou R, Shen Q, Chen LN, Jiang Z, Liu J, Zhang Y. Mao C, et al. Among authors: chen ln. Cell Res. 2020 Jul;30(7):564-573. doi: 10.1038/s41422-020-0350-5. Epub 2020 Jun 3. Cell Res. 2020. PMID: 32494023 Free PMC article.

3

A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.

Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW. Sun W, et al. Among authors: chen ln, chen y. Cell Res. 2020 Dec;30(12):1098-1108. doi: 10.1038/s41422-020-00442-0. Epub 2020 Nov 25. Cell Res. 2020. PMID: 33239759 Free PMC article.

4

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor.

Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW. Cong Z, et al. Among authors: chen ln. Nat Commun. 2021 Jun 18;12(1):3763. doi: 10.1038/s41467-021-24058-z. Nat Commun. 2021. PMID: 34145245 Free PMC article.

5

Structural insights into ligand recognition and activation of the melanocortin-4 receptor.

Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y. Zhang H, et al. Among authors: chen ln. Cell Res. 2021 Nov;31(11):1163-1175. doi: 10.1038/s41422-021-00552-3. Epub 2021 Aug 25. Cell Res. 2021. PMID: 34433901 Free PMC article.

6

Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.

Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H. Shao Z, et al. Among authors: chen zh, chen ln. Nat Chem Biol. 2022 Mar;18(3):264-271. doi: 10.1038/s41589-021-00918-z. Epub 2021 Dec 23. Nat Chem Biol. 2022. PMID: 34949837 Free PMC article.

7

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors.

Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y. Duan J, et al. Among authors: chen ln. Nat Commun. 2022 Mar 15;13(1):1364. doi: 10.1038/s41467-022-29072-3. Nat Commun. 2022. PMID: 35292680 Free PMC article.

8

Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24.

Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW. Cong Z, et al. Among authors: chen ln. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2200155119. doi: 10.1073/pnas.2200155119. Epub 2022 May 13. Proc Natl Acad Sci U S A. 2022. PMID: 35561211 Free PMC article.

9

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.

Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H. Shao Z, et al. Among authors: chen zh, chen ln. Cell Discov. 2022 May 15;8(1):44. doi: 10.1038/s41421-022-00403-4. Cell Discov. 2022. PMID: 35570218 Free PMC article.

10

Structural insights into human brain-gut peptide cholecystokinin receptors.

Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM. Ding Y, et al. Among authors: chen ln. Cell Discov. 2022 Jun 7;8(1):55. doi: 10.1038/s41421-022-00420-3. Cell Discov. 2022. PMID: 35672283 Free PMC article.

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