Chen Y - Search Results

1

Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.

Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW. Zhao F, et al. Among authors: chen ln, chen y. Nat Commun. 2022 Feb 25;13(1):1057. doi: 10.1038/s41467-022-28683-0. Nat Commun. 2022. PMID: 35217653 Free PMC article.

2

A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.

Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW. Sun W, et al. Among authors: chen ln, chen y. Cell Res. 2020 Dec;30(12):1098-1108. doi: 10.1038/s41422-020-00442-0. Epub 2020 Nov 25. Cell Res. 2020. PMID: 33239759 Free PMC article.

3

Structures of G_i-bound metabotropic glutamate receptors mGlu2 and mGlu4.

Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B. Lin S, et al. Among authors: chen y. Nature. 2021 Jun;594(7864):583-588. doi: 10.1038/s41586-021-03495-2. Epub 2021 Jun 16. Nature. 2021. PMID: 34135510

4

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor.

Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu HE, Yang D, Zhao L, Wang MW. Zhao F, et al. Among authors: chen y. Elife. 2021 Jul 13;10:e68719. doi: 10.7554/eLife.68719. Elife. 2021. PMID: 34254582 Free PMC article.

5

GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis.

Chen Y, Xu YN, Ye CY, Feng WB, Zhou QT, Yang DH, Wang MW. Chen Y, et al. Acta Pharmacol Sin. 2022 May;43(5):1156-1166. doi: 10.1038/s41401-021-00836-9. Epub 2021 Dec 21. Acta Pharmacol Sin. 2022. PMID: 34934197 Free PMC article. Review.

6

Deleterious mutation V369M in the mouse GCGR gene causes abnormal plasma amino acid levels indicative of a possible liver-α-cell axis.

Liu Q, Lin G, Chen Y, Feng W, Xu Y, Lyu J, Yang D, Wang MW. Liu Q, et al. Among authors: chen y. Biosci Rep. 2021 Jun 25;41(6):BSR20210758. doi: 10.1042/BSR20210758. Biosci Rep. 2021. PMID: 34002801 Free PMC article.

7

Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor.

Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE. Ma S, et al. Among authors: chen y. Cell Res. 2021 Oct;31(10):1061-1071. doi: 10.1038/s41422-021-00557-y. Epub 2021 Aug 27. Cell Res. 2021. PMID: 34453129 Free PMC article.

8

Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists.

Darbalaei S, Chang RL, Zhou QT, Chen Y, Dai AT, Wang MW, Yang DH. Darbalaei S, et al. Among authors: chen y. Acta Pharmacol Sin. 2023 Feb;44(2):421-433. doi: 10.1038/s41401-022-00962-y. Epub 2022 Aug 11. Acta Pharmacol Sin. 2023. PMID: 35953646 Free PMC article.

9

Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders.

Lin G, Liu Q, Dai A, Cai X, Zhou Q, Wang X, Chen Y, Ye C, Li J, Yang D, Wang MW. Lin G, et al. Among authors: chen y. Biochem J. 2020 Jul 17;477(13):2581-2594. doi: 10.1042/BCJ20200235. Biochem J. 2020. PMID: 32677665

10

High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist.

Lin G, Feng Y, Cai X, Zhou C, Shao L, Chen Y, Chen L, Liu Q, Zhou Q, Bathgate RAD, Yang D, Wang MW. Lin G, et al. Among authors: chen l, chen y. Molecules. 2021 Dec 11;26(24):7511. doi: 10.3390/molecules26247511. Molecules. 2021. PMID: 34946593 Free PMC article.

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