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Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW. Zhao F, et al. Among authors: wu b. Nat Commun. 2022 Feb 25;13(1):1057. doi: 10.1038/s41467-022-28683-0. Nat Commun. 2022. PMID: 35217653 Free PMC article.
Conformational states of the full-length glucagon receptor.
Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, Carragher B, Yang H, Wang MW, Stevens RC, Jiang H. Yang L, et al. Among authors: wu b. Nat Commun. 2015 Jul 31;6:7859. doi: 10.1038/ncomms8859. Nat Commun. 2015. PMID: 26227798 Free PMC article.
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC. Song G, et al. Among authors: wu y, wu f, wu b. Nature. 2017 Jun 8;546(7657):312-315. doi: 10.1038/nature22378. Epub 2017 May 17. Nature. 2017. PMID: 28514449
Structure of the full-length glucagon class B G-protein-coupled receptor.
Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B. Zhang H, et al. Among authors: wu y, wu x, wu b. Nature. 2017 Jun 8;546(7657):259-264. doi: 10.1038/nature22363. Epub 2017 May 17. Nature. 2017. PMID: 28514451 Free PMC article.
Extending the Structural View of Class B GPCRs.
de Graaf C, Song G, Cao C, Zhao Q, Wang MW, Wu B, Stevens RC. de Graaf C, et al. Among authors: wu b. Trends Biochem Sci. 2017 Dec;42(12):946-960. doi: 10.1016/j.tibs.2017.10.003. Epub 2017 Nov 11. Trends Biochem Sci. 2017. PMID: 29132948 Review.
Structure of the glucagon receptor in complex with a glucagon analogue.
Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B. Zhang H, et al. Among authors: wu b. Nature. 2018 Jan 3;553(7686):106-110. doi: 10.1038/nature25153. Nature. 2018. PMID: 29300013
Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor.
Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B. Yang Z, et al. Among authors: wu b. Nature. 2018 Apr;556(7702):520-524. doi: 10.1038/s41586-018-0046-x. Epub 2018 Apr 18. Nature. 2018. PMID: 29670288 Free PMC article.
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