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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.
Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF, Mendez RS, Zotta A, Peace CG, Walsh A, Chirillo R, Hams E, Fallon PG, Jayamaran R, Dua K, Brown AC, Kim RY, Horvat JC, Hansbro PM, Wang C, O'Neill LAJ. Runtsch MC, et al. Among authors: zhang y. Cell Metab. 2022 Mar 1;34(3):487-501.e8. doi: 10.1016/j.cmet.2022.02.002. Cell Metab. 2022. PMID: 35235776 Free article.
Discovery of Itaconate-Mediated Lysine Acylation.
Liu D, Xiao W, Li H, Zhang Y, Yuan S, Li C, Dong S, Wang C. Liu D, et al. Among authors: zhang y. J Am Chem Soc. 2023 Jun 14;145(23):12673-12681. doi: 10.1021/jacs.3c02332. Epub 2023 Jun 4. J Am Chem Soc. 2023. PMID: 37271942
Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke.
Wei C, Xiao Z, Zhang Y, Luo Z, Liu D, Hu L, Shen D, Liu M, Shi L, Wang X, Lan T, Dai Q, Liu J, Chen W, Zhang Y, Sun Q, Wu W, Wang P, Zhang C, Hu J, Wang C, Yang F, Li Q. Wei C, et al. Among authors: zhang c, zhang y. Cell Death Differ. 2024 Aug;31(8):983-998. doi: 10.1038/s41418-024-01303-8. Epub 2024 May 8. Cell Death Differ. 2024. PMID: 38719928
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