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Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments.
Habota T, Sandu AL, Waiter GD, McNeil CJ, Steele JD, Macfarlane JA, Whalley HC, Valentine R, Younie D, Crouch N, Hawkins EL, Hirose Y, Romaniuk L, Milburn K, Buchan G, Coupar T, Stirling M, Jagpal B, MacLennan B, Priba L, Harris MA, Hafferty JD, Adams MJ, Campbell AI, MacIntyre DJ, Pattie A, Murphy L, Reynolds RM, Elliot R, Penton-Voak IS, Munafò MR, Evans KL, Seckl JR, Wardlaw JM, Lawrie SM, Haley CS, Porteous DJ, Deary IJ, Murray AD, McIntosh AM. Habota T, et al. Among authors: murphy l. Wellcome Open Res. 2021 Jul 16;4:185. doi: 10.12688/wellcomeopenres.15538.2. eCollection 2019. Wellcome Open Res. 2021. PMID: 35237729 Free PMC article.
Genetic and environmental exposures constrain epigenetic drift over the human life course.
Shah S, McRae AF, Marioni RE, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR, Pattie A, Corley J, Murphy L, Martin NG, Montgomery GW, Starr JM, Wray NR, Deary IJ, Visscher PM. Shah S, et al. Among authors: murphy l. Genome Res. 2014 Nov;24(11):1725-33. doi: 10.1101/gr.176933.114. Epub 2014 Sep 23. Genome Res. 2014. PMID: 25249537 Free PMC article.
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936.
Marioni RE, Shah S, McRae AF, Ritchie SJ, Muniz-Terrera G, Harris SE, Gibson J, Redmond P, Cox SR, Pattie A, Corley J, Taylor A, Murphy L, Starr JM, Horvath S, Visscher PM, Wray NR, Deary IJ. Marioni RE, et al. Among authors: murphy l. Int J Epidemiol. 2015 Aug;44(4):1388-96. doi: 10.1093/ije/dyu277. Epub 2015 Jan 22. Int J Epidemiol. 2015. PMID: 25617346 Free PMC article.
Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936.
Harris SE, Riggio V, Evenden L, Gilchrist T, McCafferty S, Murphy L, Wrobel N, Taylor AM, Corley J, Pattie A, Cox SR, Martin-Ruiz C, Prendergast J, Starr JM, Marioni RE, Deary IJ. Harris SE, et al. Among authors: murphy l. Aging (Albany NY). 2017 Dec 1;9(12):2489-2503. doi: 10.18632/aging.101333. Aging (Albany NY). 2017. PMID: 29207374 Free PMC article.
Assessment of dried blood spots for DNA methylation profiling.
Walker RM, MacGillivray L, McCafferty S, Wrobel N, Murphy L, Kerr SM, Morris SW, Campbell A, McIntosh AM, Porteous DJ, Evans KL. Walker RM, et al. Among authors: murphy l. Wellcome Open Res. 2019 Mar 6;4:44. doi: 10.12688/wellcomeopenres.15136.1. eCollection 2019. Wellcome Open Res. 2019. PMID: 30984878 Free PMC article.
A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens.
Stevenson AJ, McCartney DL, Gadd DA, Shireby G, Hillary RF, King D, Tzioras M, Wrobel N, McCafferty S, Murphy L, McColl BW, Redmond P, Taylor AM, Harris SE, Russ TC, McIntosh AM, Mill J, Smith C, Deary IJ, Cox SR, Marioni RE, Spires-Jones TL. Stevenson AJ, et al. Among authors: murphy l. Eur J Neurosci. 2022 Nov;56(9):5637-5649. doi: 10.1111/ejn.15661. Epub 2022 Apr 6. Eur J Neurosci. 2022. PMID: 35362642 Free PMC article.
Feasibility and ethics of using data from the Scottish newborn blood spot archive for research.
Cunningham-Burley S, McCartney DL, Campbell A, Flaig R, Orange CEL, Porteous C, Aitken M, Mulholland C, Davidson S, McCafferty SM, Murphy L, Wrobel N, McCafferty S, Wallace K, StClair D, Kerr S, Hayward C, McIntosh AM, Sudlow C, Marioni RE, Pell J, Miedzybrodzka Z, Porteous DJ. Cunningham-Burley S, et al. Among authors: murphy l. Commun Med (Lond). 2022 Oct 6;2:126. doi: 10.1038/s43856-022-00189-2. eCollection 2022. Commun Med (Lond). 2022. PMID: 36210800 Free PMC article.
Refining epigenetic prediction of chronological and biological age.
Bernabeu E, McCartney DL, Gadd DA, Hillary RF, Lu AT, Murphy L, Wrobel N, Campbell A, Harris SE, Liewald D, Hayward C, Sudlow C, Cox SR, Evans KL, Horvath S, McIntosh AM, Robinson MR, Vallejos CA, Marioni RE. Bernabeu E, et al. Among authors: murphy l. Genome Med. 2023 Feb 28;15(1):12. doi: 10.1186/s13073-023-01161-y. Genome Med. 2023. PMID: 36855161 Free PMC article.
Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes.
Cheng Y, Gadd DA, Gieger C, Monterrubio-Gómez K, Zhang Y, Berta I, Stam MJ, Szlachetka N, Lobzaev E, Wrobel N, Murphy L, Campbell A, Nangle C, Walker RM, Fawns-Ritchie C, Peters A, Rathmann W, Porteous DJ, Evans KL, McIntosh AM, Cannings TI, Waldenberger M, Ganna A, McCartney DL, Vallejos CA, Marioni RE. Cheng Y, et al. Among authors: murphy l. Nat Aging. 2023 Apr;3(4):450-458. doi: 10.1038/s43587-023-00391-4. Epub 2023 Apr 6. Nat Aging. 2023. PMID: 37117793
2,053 results