Fraser JS - Search Results

1

Accurate positioning of functional residues with robotics-inspired computational protein design.

Krivacic C, Kundert K, Pan X, Pache RA, Liu L, Conchúir SO, Jeliazkov JR, Gray JJ, Thompson MC, Fraser JS, Kortemme T. Krivacic C, et al. Among authors: fraser js. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2115480119. doi: 10.1073/pnas.2115480119. Epub 2022 Mar 7. Proc Natl Acad Sci U S A. 2022. PMID: 35254891 Free PMC article.

2

Accessing protein conformational ensembles using room-temperature X-ray crystallography.

Fraser JS, van den Bedem H, Samelson AJ, Lang PT, Holton JM, Echols N, Alber T. Fraser JS, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16247-52. doi: 10.1073/pnas.1111325108. Epub 2011 Sep 14. Proc Natl Acad Sci U S A. 2011. PMID: 21918110 Free PMC article.

3

Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair.

Kapp GT, Liu S, Stein A, Wong DT, Reményi A, Yeh BJ, Fraser JS, Taunton J, Lim WA, Kortemme T. Kapp GT, et al. Among authors: fraser js. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5277-82. doi: 10.1073/pnas.1114487109. Epub 2012 Mar 7. Proc Natl Acad Sci U S A. 2012. PMID: 22403064 Free PMC article.

4

Flexible backbone sampling methods to model and design protein alternative conformations.

Ollikainen N, Smith CA, Fraser JS, Kortemme T. Ollikainen N, et al. Among authors: fraser js. Methods Enzymol. 2013;523:61-85. doi: 10.1016/B978-0-12-394292-0.00004-7. Methods Enzymol. 2013. PMID: 23422426 Free PMC article.

5

Protein structural ensembles are revealed by redefining X-ray electron density noise.

Lang PT, Holton JM, Fraser JS, Alber T. Lang PT, et al. Among authors: fraser js. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):237-42. doi: 10.1073/pnas.1302823110. Epub 2013 Dec 20. Proc Natl Acad Sci U S A. 2014. PMID: 24363322 Free PMC article.

6

Conformational dynamics of a crystalline protein from microsecond-scale molecular dynamics simulations and diffuse X-ray scattering.

Wall ME, Van Benschoten AH, Sauter NK, Adams PD, Fraser JS, Terwilliger TC. Wall ME, et al. Among authors: fraser js. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17887-92. doi: 10.1073/pnas.1416744111. Epub 2014 Dec 1. Proc Natl Acad Sci U S A. 2014. PMID: 25453071 Free PMC article.

7

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.

Keedy DA, Kenner LR, Warkentin M, Woldeyes RA, Hopkins JB, Thompson MC, Brewster AS, Van Benschoten AH, Baxter EL, Uervirojnangkoorn M, McPhillips SE, Song J, Alonso-Mori R, Holton JM, Weis WI, Brunger AT, Soltis SM, Lemke H, Gonzalez A, Sauter NK, Cohen AE, van den Bedem H, Thorne RE, Fraser JS. Keedy DA, et al. Among authors: fraser js. Elife. 2015 Sep 30;4:e07574. doi: 10.7554/eLife.07574. Elife. 2015. PMID: 26422513 Free PMC article.

8

Measuring and modeling diffuse scattering in protein X-ray crystallography.

Van Benschoten AH, Liu L, Gonzalez A, Brewster AS, Sauter NK, Fraser JS, Wall ME. Van Benschoten AH, et al. Among authors: fraser js. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4069-74. doi: 10.1073/pnas.1524048113. Epub 2016 Mar 28. Proc Natl Acad Sci U S A. 2016. PMID: 27035972 Free PMC article.

9

Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting.

Mavor D, Barlow K, Thompson S, Barad BA, Bonny AR, Cario CL, Gaskins G, Liu Z, Deming L, Axen SD, Caceres E, Chen W, Cuesta A, Gate RE, Green EM, Hulce KR, Ji W, Kenner LR, Mensa B, Morinishi LS, Moss SM, Mravic M, Muir RK, Niekamp S, Nnadi CI, Palovcak E, Poss EM, Ross TD, Salcedo EC, See SK, Subramaniam M, Wong AW, Li J, Thorn KS, Conchúir SÓ, Roscoe BP, Chow ED, DeRisi JL, Kortemme T, Bolon DN, Fraser JS. Mavor D, et al. Among authors: fraser js. Elife. 2016 Apr 25;5:e15802. doi: 10.7554/eLife.15802. Elife. 2016. PMID: 27111525 Free PMC article.

10

Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.

Biel JT, Thompson MC, Cunningham CN, Corn JE, Fraser JS. Biel JT, et al. Among authors: fraser js. Structure. 2017 May 2;25(5):739-749.e3. doi: 10.1016/j.str.2017.03.009. Epub 2017 Apr 13. Structure. 2017. PMID: 28416112 Free PMC article.

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