Simeonov A - Search Results

1

A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System.

Cheng E, Dorjsuren D, Lehman S, Larson CL, Titus SA, Sun H, Zakharov A, Rai G, Heinzen RA, Simeonov A, Machner MP. Cheng E, et al. Among authors: simeonov a. mBio. 2022 Apr 26;13(2):e0024022. doi: 10.1128/mbio.00240-22. Epub 2022 Mar 8. mBio. 2022. PMID: 35258332 Free PMC article.

2

A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.

Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. Lea WA, et al. Among authors: simeonov a. Assay Drug Dev Technol. 2008 Aug;6(4):551-5. doi: 10.1089/adt.2008.149. Assay Drug Dev Technol. 2008. PMID: 18665782 Free PMC article.

3

Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.

Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM 3rd. Simeonov A, et al. PLoS One. 2009 Jun 1;4(6):e5740. doi: 10.1371/journal.pone.0005740. PLoS One. 2009. PMID: 19484131 Free PMC article.

4

A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases.

Dorjsuren D, Wilson DM 3rd, Beard WA, McDonald JP, Austin CP, Woodgate R, Wilson SH, Simeonov A. Dorjsuren D, et al. Among authors: simeonov a. Nucleic Acids Res. 2009 Oct;37(19):e128. doi: 10.1093/nar/gkp641. Epub 2009 Aug 14. Nucleic Acids Res. 2009. PMID: 19684079 Free PMC article.

5

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J. Auld DS, et al. Among authors: simeonov a. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. doi: 10.1073/pnas.0909141107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194791 Free PMC article.

6

Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ. Rai G, et al. Among authors: simeonov a. J Med Chem. 2010 Oct 28;53(20):7392-404. doi: 10.1021/jm1008852. J Med Chem. 2010. PMID: 20866075 Free PMC article.

7

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity.

Dorjsuren D, Kim D, Maloney DJ, Wilson DM 3rd, Simeonov A. Dorjsuren D, et al. Among authors: simeonov a. Nucleic Acids Res. 2011 Jan;39(2):e11. doi: 10.1093/nar/gkq1082. Epub 2010 Nov 9. Nucleic Acids Res. 2011. PMID: 21062821 Free PMC article.

8

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB 2nd, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR. Kenyon V, et al. Among authors: simeonov a. J Med Chem. 2011 Aug 11;54(15):5485-97. doi: 10.1021/jm2005089. Epub 2011 Jul 8. J Med Chem. 2011. PMID: 21739938 Free PMC article.

9

Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.

Rai G, Vyjayanti VN, Dorjsuren D, Simeonov A, Jadhav A, Wilson DM 3rd, Maloney DJ. Rai G, et al. Among authors: simeonov a. J Med Chem. 2012 Apr 12;55(7):3101-12. doi: 10.1021/jm201537d. Epub 2012 Mar 28. J Med Chem. 2012. PMID: 22455312 Free PMC article.

10

A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.

Yamanaka K, Dorjsuren D, Eoff RL, Egli M, Maloney DJ, Jadhav A, Simeonov A, Lloyd RS. Yamanaka K, et al. Among authors: simeonov a. PLoS One. 2012;7(10):e45032. doi: 10.1371/journal.pone.0045032. Epub 2012 Oct 8. PLoS One. 2012. PMID: 23056190 Free PMC article.

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